研究血清多种肿瘤标志物联合检测对结直肠癌的诊断意义

Study on the diagnostic Significance of Serum Tumor Markers combined with Detection in colorectal Cancer

目的探讨血清中肿瘤标志物CA125、CA242、CA50、CA19-9及CEA单项和联合检测对结直肠癌的诊断意义,为临床应用提供参考依据。方法从民航上海医院2016年1月—2019年1月期间收治的结直肠癌患者中选取120例,记为结直肠癌组,选取同期60例结直肠良性病变患者记为良性病变组,同时将60例同期在本院接受体检的健康者记为健康对照组。采集上述三组对象的外周血,利用化学发光法检测其血清中CA125、CA242、CA50、CA19-9和CEA的水平。结果结直肠癌组患者血清中CA125、CA242、CA50、CA19-9和CEA的水平均显著高于良性病变组和健康对照组(均P<0.05);良性病变组患者血清中上述各指标均显著高于健康对照组,差异均具有统计学意义(均P<0.05)。肿瘤标志物CA125、CA242、CA50、CA19-9和CEA联合检测相对单项检测具有更高的准确性和敏感度(P<0.05)。结论血清中CA125、CA242、CA50、CA19-9和CEA肿瘤标志物的联合检测无论对结直肠癌的诊断鉴别,还是对其TNM分期判断均具有重要的作用,该方法可用于结直肠癌的早期诊断筛查。

Objective To investigate the diagnostic significance of single and combined detection of serum tumor markers CA125,CA242,CA50,CA19-9 and CEA in colorectal cancer,to provide reference basis for clinical application.Methods From January 2016 to January 2019,120 patients with colorectal cancer were enrolled as colorectal cancer group,and 60 patients with benign colorectal disease were enrolled as benign disease group,at the same time,60 healthy persons who accepted physical examination in our hospital at the same time were recorded as healthy control group.Peripheral blood was collected from the three groups of subjects,the serum levels of CA125,CA242,CA50,CA19-9 and CEA were measured by chemiluminescence method.Results The levels of serum CA125,CA242,CA50,CA19-9 and CEA in patients with colorectal cancer were significantly higher than those in patients with benign lesions and healthy controls(P<0.05).The abovementioned indexes in patients with benign lesions were significantly higher than those in healthy control group(P<0.05).The combined detection of CA125,CA242,CA50,CA19-9 and CEA were more accurate and sensitive than single detection(P<0.05).Conclusion The combined detection of serum CA125,CA242,CA50,CA19-9 and CEA tumor markers plays an important role in the diagnosis and TNM staging of colorectal cancer,this method can be used for early diagnosis and screening of colorectal cancer.