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外周血炎症细胞因子在结直肠癌预后中的研究进展 被引量:6

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摘要 结直肠癌(CRC)是中国较常见的消化系统恶性肿瘤之一,发病率和病死率均呈逐年升高趋势,严重影响人们的身体健康。研究CRC的影响因素对CRC患者的预后预测和深化治疗具有重要意义。炎症反应被认为是包括CRC在内的各种类型肿瘤的不良预后因素,并与恶性肿瘤的生物学行为和机体恶化的营养状况有关。中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)与肿瘤的侵袭、复发、转移及预后密切相关,已被广泛用作恶性肿瘤患者预后的炎症反应评估指标。升高的PLR和NLR是影响CRC患者预后的独立危险因素,且在预测CRC患者的预后方面,PLR的预测效果优于NLR。本文从中性粒细胞、淋巴细胞、血小板与肿瘤的关系,外周血NLR、PLR与CRC患者预后的关系等方面进行简要综述,旨在为改善CRC患者的预后、及时调整CRC患者的治疗方案提供科学证据。
出处 《癌症进展》 2020年第15期1522-1525,1600,共5页 Oncology Progress
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