连夏芪麦汤结合隔物灸法对慢性胃炎患者胃肠激素水平的影响

Effect of Lianxia Qimai decoction combined with sandwiched moxibustion on gastrointestinal hormone levels in patients with chronic gastritis

目的探讨连夏芪麦汤结合隔物灸法对慢性胃炎患者胃肠激素水平的影响。方法回顾性分析2017年4月至2020年1月某院收治的80例慢性胃炎患者的临床资料,根据治疗方法的不同进行分组,将其中40例采用隔物灸法治疗的患者纳入对照组,将另外40例联合连夏芪麦汤治疗的患者纳入观察组。比较两组治疗前、治疗2个月后中医证候积分(包括胃脘胀满、口干口苦、嗳气反酸、便溏)以及胃肠激素水平[包括胃动素(MTL)、胃泌素(GAS)、P物质(SP)]。结果治疗后,两组胃脘胀满、口干口苦、嗳气反酸以及便溏证候评分均下降,且观察组胃脘胀满、口干口苦、嗳气反酸以及便溏证候评分(0.79±0.23)分、(1.02±0.30)分、(0.68±0.27)分、(0.53±0.19)分低于对照组(1.20±0.38)分、(1.25±0.41)分、(0.99±0.32)分、(0.76±0.30)分,差异有统计学意义(P<0.05);治疗后,两组MTL、GAS、SP水平均上升,且观察组MTL、GAS、SP水平(326.72±50.45)ng/L、(49.90±6.16)ng/L、(25.86±4.28)ng/L高于对照组(283.09±46.32)ng/L、(41.26±5.48)ng/L、(20.75±3.67)ng/L,差异有统计学意义(P<0.05)。结论连夏芪麦汤结合隔物灸法治疗慢性胃炎效果显著,可减轻患者临床症状,调节其胃肠激素水平。

Objective To investigate the effects of Lianxia Qimai decoction combined with sandwiched moxibustion on gastrointestinal hormone levels in patients with chronic gastritis.Methods The clinical data of 80 patients with chronic gastritis admitted to a hospital from April 2017 to January 2020 were retrospectively analyzed.According to different treatment methods,40 patients treated with septal moxibustion were included in the control group,and the other 40 patients treated with additional Lianxia Qimai decoction were included in the observation group.TCM syndrome scores(including epigastric distension and fullness,dry mouth and bitter mouth,belching acid regurgitation,and stool)and gastrointestinal hormone levels(including motilin(MTL),gastrin(GAS),substance P(SP)were compared between the two groups before treatment and 2 months after treatment.Results After treatment,the syndrome scores of epigastric distension and fullness,dry mouth and bitter mouth,belching acid regurgitation,and stool in the two groups all decreased,and the syndrome scores of epigastric distension and fullness,dry mouth and bitter mouth,belching acid regurgitation,and stool in the observation group(0.79±0.23),(1.02±0.30),(0.68±0.27),(0.53±0.19)were lower than those in the control group(1.20±0.38),(1.25±0.41),(0.99±0.32),(0.76±0.30),the difference was statistically significant(P<0.05);After treatment,MTL,GAS and SP levels in both groups increased,and MTL,GAS and SP levels in the observation group(326.72±50.45)ng/L,(49.90±6.16)ng/L,(25.86±4.28)ng/L were higher than those in the control group(283.09±46.32)ng/L,(41.26±5.48)ng/L,and(20.75±3.67)ng/L,with statistically significant differences(P<0.05).Conclusion Lianxia Qimai decoction combined with sandwiched moxibustion therapy for chronic gastritis has significant effects,which can reduce the clinical symptoms of patients and adjust the levels of gastrointestinal hormones.