中国人群PSCA基因rs2976392多态位点与胃癌易感性Meta分析

Association between PSCA gene rs2976392 polymorphism and susceptibility of gastric cancer in Chinese population:a meta-analysis

目的评价前列腺干细胞抗原(prostate stem cell antigen,PSCA)基因rs2976392多态位点与中国人群胃癌易感性的关联。方法通过计算机检索中国知网、万方数据库、维普数据库、NCBI、Embase、Web of Science等数据库获取关于胃癌与PSCA基因rs2976392多态位点相关的文献,检索时间为自建库起至2020年3月22日。对纳入文献进行质量评价后,使用RevMan 5.3和Stata 12.0软件进行Meta分析。结果最终纳入13篇文献共14项病例对照研究,包含6618例胃癌患者和6952例对照者。Meta分析显示,等位基因模型(A vs G)、显性基因模型(AA+GA vs GG)和1个共显性基因模型(AA vs GG)均显示PSCA基因rs2976392多态位点与中国人群胃癌发病风险增加有关(OR=1.28,95%CI:1.08~1.52,P=0.004;OR=1.35,95%CI:1.27~1.45,P<0.001;OR=1.51,95%CI:1.03~2.20,P=0.030)。亚组分析结果显示,所有基因模型均与汉族人群胃癌发病风险增加有关(均P<0.001),但与藏族人群胃癌发病风险无关(均P>0.05)。结论PSCA基因rs2976392多态位点与中国人群胃癌发病风险升高有关,且以纯合AA基因型汉族人群的胃癌发病风险最高。

Objective To evaluate the association between prostate stem cell antigen(PSCA)gene rs2976392 polymorphism and susceptibility of gastric cancer in Chinese population.Methods Databases including CKNI,Wanfang,VIP,NCBI,Embase,and Web of Science were searched to identify the literatures concerning the association between PSCA gene rs2976392 polymorphism and susceptibility of gastric cancer in Chinese population from the inception to March 22,2020.Meta-analysis was performed using Rev Man 5.3 and Stata 12 software after quality assessment.Results A total of 14 case-control studies from 13 literatures were included,involving 6618 gastric cancer cases and 6952 controls.The meta-analysis results of allele model(A vs G),dominant gene model(AA+GA vs GG)and a codominant gene model(AA vs GG)all showed that the PSCA gene rs2976392 polymorphism was associated with an increased risk of gastric cancer in the Chinese population(OR=1.28,95%CI:1.08-1.52,P=0.004;OR=1.35,95%CI:1.27-1.45,P<0.001;OR=1.51,95%CI:1.03-2.20,P=0.030).The subgroup analysis showed that all the gene models were associated with an increased risk of gastric cancer in Han population(all P<0.001),but in Tibetan population,all genetic models showed no obvious correlation(all P>0.05).Conclusions PSCA gene rs2976392 polymorphisms is associated with an increasing risk of gastric cancer in Chinese population,and the risk of gastric cancer in the Han population homozygous for the AA genotype is highest.