血小板输注疗效的影响因素分析

Analysis on the influencing factors of efficiency of platelet transfusion

目的分析血小板输注疗效的影响因素。方法观察84例血小板输注治疗患者共363次血小板输注的治疗效果,运用校正血小板增加值和血小板回收率作为量化判断标准,并结合患者的临床出血表现,综合分析患者各项临床基本情况对血小板输注疗效的影响。结果二分类Logistic回归分析结果显示,细菌培养阳性(OR=1.752,95%CI:1.055~2.910)、脾大(OR=2.133,95%CI:1.035~4.395)及活动性出血(OR=1.784,95%CI:1.113~2.861)为血小板输注无效的危险因素(P<0.05)。结论影响血小板输注疗效的因素包括细菌培养阳性、脾大及活动性出血。

Objective To analyze the influencing factors of efficiency of platelet transfusion.Methods The therapeutic effect of 84 patients treated with 363 platelet transfusions was observed.Using correction of platelet increment and platelet recovery rate as the quantitative judgment criteria,and combining with the clinical manifestations of hemorrhage of the patients,the influence of each clinical basic situation of the patients on the efficiency of platelet transfusion was comprehensively analyzed.Results Binary Logistic regression analysis showed that positive bacterial culture(OR=1.752,95%CI:1.055~2.910),splenomegaly(OR=2.133,95%CI:1.035~4.395)and active hemorrhage(OR=1.784,95%CI:1.113~2.861)were the risk factors of platelet transfusion refractoriness(P<0.05).Conclusion The influencing factors of efficiency of platelet transfusion are positive bacterial culture,splenomegaly and active hemorrhage.