雾化吸入乙酰半胱氨酸治疗囊状支气管扩张症的效果探究

Effect of Aerosol Inhalation of Acetyl Cysteine on Cystic Bronchiectasis

目的探究乙酰半胱氨酸雾化治疗囊状支气管扩张症的临床应用效果。方法选取山东省德州市市立医院2016年2月至2018年10月收治的90例囊状支气管扩张症患者,按照随机数字表法分为雾化组和常规组,每组各45例。对比2组患者治疗后咳嗽、呼吸及生活质量的改善情况,以及急性加重时间情况。结果雾化组的改良版呼吸问卷(mMRC)、呼吸问题调查问卷(SGRQ)均比常规组低(P<0.05),其莱切斯特咳嗽问卷(LCQ)评分比常规组高(P<0.05),且雾化组的首次急性加重时间比常规组延迟(P<0.05),而2组患者1年内急性加重次数相比,差异无统计学意义(P>0.05)。结论乙酰半胱氨酸雾化治疗囊状支气管扩张症可有效缓解患者咳嗽、呼吸困难等症状,提高患者生活质量,效果好,值得临床推广应用。

Objective To explore the clinical effect of acetylcysteine atomization in the treatment of cystic bronchiectasis.Methods A total of 90 patients with cyst bronchiectasis admitted to Dezhou Municipal Hospital of Shandong Province from February 2016 to October 2018 were selected and divided into atomization group and conventional group according to the random number table method,with 45 patients in each group.The improvement of cough,respiration and quality of life after treatment and the time of acute exacerbation were compared between the two groups.Results Atomization group modified respiratory questionnaire(mMRC),respiratory problem questionnaire(SGRQ)are lower than normal group(P<0.05),the leicester cough questionnaire(LCQ)score is higher than conventional group(P<0.05),and the atomization group of exacerbations than routine group delay for the first time(P<0.05),1 year and 2 groups of patients compared to the number of exacerbations,there was no statistically significant difference(P>0.05).Conclusion Acetylcysteine atomization treatment of cystic bronchiectasis can effectively relieve the symptoms of cough,dyspnea,improve the quality of life of the patients,the prognosis is good,it is worthy of clinical application.