埃索美拉唑联合多潘立酮治疗反流性食管炎疗效观察

Clinical Observation of Esomeprazole Combined with Domperidone in the Treatment of Reflux Esophagitis

目的埃索美拉唑联合多潘立酮治疗反流性食管炎疗效观察。方法选取安达市利达医院2018年10月至2019年10月收治的82例反流性食管炎患者作为研究对象,按照入院先后顺序分为治疗组(n=41例)与对照组(n=41例)。治疗组患者采用埃索美拉唑联合多潘立酮治疗,对照组患者采用莫沙必利联合多潘立酮治疗。比较2组治疗后临床治疗效果、患者负性情绪变化情况、临床指标情况及患者生活质量。结果治疗后,治疗组治疗有效率及生活质量评分明显高于对照组,负性情绪评分及临床指标评分明显低于对照组,差异均有统计学意义(P<0.05)。结论埃索美拉唑联合多潘立酮对反流性食管炎具有显著的临床治疗效果,既能改善患者负性情绪,又能缓解临床指标情况,提高患者生活质量。

Objective To observe the effect of esomeprazole combined with domperidone in the treatment of reflux esophagitis.Methods Totally 82 patients with reflux esophagitis admitted to Lida Hospital in Anda City from October 2018 to October 2019 were selected as the subjects of the study.According to the order of admission,82 patients were divided into the treatment group(41 cases)and control group(41cases).The treatment group was treated with esomeprazole combined with domperidone,the control group was treated with mosapride combined with domperidone.The clinical effect,patients'negative mood changes,clinical indexes and the patients’quality of life were compared between the two groups after treatment.Results After treatment,the therapeutic efficiency and quality of life scores of the treatment group were significantly higher than those of the control group,and the negative mood scores and clinical indicators scores of the treatment group were significantly lower than those of the control group,with statistically significant differences(P<0.05).Conclusion Esomeprazole combined with domperidone had a significant clinical effect on reflux esophagitis,which can not only improve patients'negative mood,but also alleviate patients'clinical indicators and quality of life.