老年消化性溃疡复发33例分析

Analysis of recurrent peptic ulcer in the 33 elderly cases

目的探讨老年病人消化性溃疡复发因素。方法收集合肥市第二人民医院消化内科2017年1月至2018年6月诊治的老年消化性溃疡病人116例临床资料,随访1年内病人溃疡是否复发,分析与其相关的临床因素。结果排除病史不全4例及随访脱落5例,最终纳入107例。本次纳入研究的病人溃疡复发率31%,其中随访末期幽门螺杆菌(Hp)感染状态(OR=45.682,95%CI:2.654~702.832)、服用非甾体抗炎药(NSAID)(OR=6.328,95%CI:1.387~27.896)及吸烟(OR=1.805,95%CI:1.189~2.687)与老年消化性溃疡复发相关。结论老年消化性溃疡病人的复发率较高。随访末期Hp感染状态、服用NSAID药物及吸烟与其相关。临床工作应重视合并多种复发因素的老年病人,有针对性地调整诊疗方案以降低溃疡复发风险。

Objective To investigate the related factors of peptic ulcer recurrence in elderly patients.Methods The clinical data of 116 elderly patients with peptic ulcer diagnosed and treated in department of Gastroenterology,Hefei Second People’s Hospital from January 2017 to June 2018 were collected.And followed⁃up for 1 year to see if the ulcer recurred and the relevant clinical fac⁃tors were analyzed.Results 4 cases of incomplete medical history and 5 cases of follow⁃up dropped out were excluded,and 107 cases were finally included.The recurrence rate of ulcers in this study was 31%,including Helicobacter pylori(Hp)infection status(OR=45.682,95%CI:2.654⁃702.832)and taking non⁃steroidal anti⁃inflammatory drugs(NSAID)(OR=6.328,95%CI:1.387⁃27.896)and smoking(OR=1.805,95%CI:1.189⁃2.687)are associated with recurrence of peptic ulcer in the elderly patients.Conclusions The recurrence rate of elderly patients with peptic ulcer is relatively high.At the end of follow⁃up,Hp infection sta⁃tus,taking NSAID drugs and smoking are related to it.The clinical work should pay attention to the elderly patients with multiple ulcer recurrence factors,and adjust the diagnosis and treatment plan to reduce the risk of ulcer recurrence.