血清S100B自身抗体在肺癌脑转移中的应用价值

Application value of serum S100B autoantibody in lung cancer with brain metastasis

目的检测肺癌脑转移患者血清S100B自身抗体水平,探讨其在肺癌脑转移中的应用价值。方法建立检测S100B抗体的间接ELISA方法,分别检测肺癌脑转移组(111例)、肺癌其他转移组(32例)、肺癌无转移组(53例)及对照组(40例)的血清S100B抗体水平,比较各组间差异并制作ROC曲线。结果肺癌脑转移组S100B抗体水平高于肺癌无转移组、肺癌其他转移组和对照组(P<0.05);肺癌无转移组与肺癌其他转移组、对照组S100B抗体水平差异无统计学意义(P>0.05)。肺癌脑转移组S100B抗体水平与病理分型、肿瘤年限、年龄、性别、吸烟史均无关(P>0.05)。S100B抗体诊断肺癌脑转移的AUC为0.704,敏感度为48.6%,特异度为86.4%。结论S100B抗体诊断肺癌脑转移具有一定的灵敏度和特异性,能鉴别肺癌脑转移和其他部位的转移,且不受病理分型、肿瘤年限等因素的影响,具有较大的临床价值。

Objective To detect the levels of serum S100 B autoantibody in patients with brain metastases of lung cancer,and explore the application value of S100 B autoantibody in lung cancer with brain metastases.Methods An indirect ELISA was established,the level of serum S100 B autoantibody was detected respectively in the brain metastasis of lung cancer group(111 cases),the lung cancer without metastasis group(53 cases),the lung cancer with other parts metastasis group(32 cases)and the control group(40 healthy volunteers).ROC Curve was used to evaluate the assay.Results The level of S100 B antibody in lung cancer brain metastasis group was higher than that in lung cancer non-metastasis group,other lung cancer metastasis group and control group(P<0.05).There was no statistical significance on the difference in S100 B antibody level between the lung cancer non-metastasis group,other lung cancer metastasis groups and the control group(P>0.05).The level of S100 B antibody in the lung cancer brain metastasis group was not correlated with pathological type,tumor age,age,gender and smoking history(P>0.05).The AUC,sensitivity and specificity of S100 B antibody in the diagnosis of lung cancer brain metastasis were respectively 0.704,48.6%and 86.4%.Conclusion S100 B autoantibody has a certain sensitivity and specificity in the diagnosis of brain metastasis of lung cancer.It can distinguish between the brain metastasis of lung cancer and the lung cancer with other parts metastasis,and it is not affected by the factors such as pathological type and tumor age.Therefore,the serum S100 B autoantibody is of great clinical value for brain metastases from lung cancer.