肺功能异常对多发性骨髓瘤患者预后的影响

The Effect of Pulmonary Dysfunction on the Prognosis of Multiple Myeloma

目的评估肺功能异常对多发性骨髓瘤(MM)患者预后的影响。方法对60例新诊断MM的患者,评估肺功能之后,进行30月随访,观察肺功能与患者预后的联系。结果27例患者(45.0%)有阻塞性或限制性肺功能缺损。阻塞性肺缺损患者的OS(生存率)明显低于限制性或肺功能正常患者。在多变量分析中,只有高危细胞遗传学和PEF和/或DLCO<65%是独立的预后影响因素。结论PEF和DLCO可作为新诊断MM患者OS重要预测指标,在初步评估中发挥作用。

Objective To evaluate the effect of pulmonary dysfunction on the prognosis of multiple myeloma(MM).Methods We prospectively performed PFTs in 60 newly diagnosed MM patients,before initiation of treatment,and we evaluated possible associations of lung function with their outcomes for 30 months.Results 27 patients(45.0%)had either obstructive or restrictive pulmonary function defects.The survival was significantly worse in those with obstructive pulmonary defect vs.those with restrictive or normal lung function.In the multivariate analysis,only the presence of high-risk cytogenetics and presence of either or both PEF and DLCO<65%of predicted were independent prognostic factors.Conclusion PEF and DLCO could be useful in the initial assessment of newly diagnosed MM patients as significant predictors of survival.