丹白颗粒联合阿奇霉素治疗慢性盆腔炎的疗效分析

Therapeutic Effects of Danbai Granules Combined with Azithromycin on Chronic Pelvic Inflammatory Disease

目的:探究丹白颗粒联合阿奇霉素对慢性盆腔炎的治疗效果。方法:选取2018年12月至2019年2月山东省日照市人民医院收治的支原体感染导致的慢性盆腔炎患者110例作为研究对象,按照随机数字表法分为对照组和观察组,每组55例。对照组患者单纯给予阿奇霉素治疗,观察组患者在对照组基础上加用丹白颗粒治疗。观察2组患者治疗期间的显效时间、临床疗效、不良反应和复发率发生情况。治疗前、治疗后子宫低切全血黏度、高切全血黏度、血浆黏度、红细胞聚集指数、红细胞压积(%)、红细胞沉降率和纤维蛋白原血流动力学指标的变化情况以及TNF-α、IL-8和IL-10的水平变化情况。结果观察组显效时间显著低于对照组;观察组总有效率为98.2%,显著高于对照组的90.9%;观察组的不良反应的复发率发生情况同样显著低于对照组;2组患者血流动力学各项指标与组内治疗前比较,差异均有统计学意义(P均<0.05);治疗后观察组患者血流变学各项指标与对照组比较,差异均有统计学意义(P均<0.05);2组患者治疗后TNF-α、IL-8和IL-10水平均比组内治疗前显著降低;与对照组比较,观察组TNF-α、IL-8和IL-10水平下降更明显,差异均有统计学意义(P均<0.05)。结论:丹白颗粒联阿奇霉素治疗慢性盆腔炎可能是通过影响患者血液中TNF-α、IL-8和IL-10表达水平来改善其子宫血流动力学指标,最终提高治疗,降低复发率和不良反应发生率。

Objective:To explore the therapeutic effects of Danbai Granules combined with azithromycin on chronic pelvic inflammatory disease.Methods:A total of 110 patients with chronic pelvic inflammatory disease caused by mycoplasma infection admitted from December 2018 to February 2019 in Tianjin University of Traditional Chinese Medicine were divided into a control group and an observation group according to random number table,with 55 cases in each group.Patients in the control group were treated with azithromycin alone,and patients in the observation group were treated with Danbai Granules on the basis of the control group.The effective time,clinical efficacy,adverse reactions and recurrence rate of the 2 groups were observed.Changes in uterine hypotensive whole blood viscosity,high cut whole blood viscosity,plasma viscosity,erythrocyte aggregation index,hematocrit(%),erythrocyte sedimentation rate and fibrinogen hemodynamics before and after treatment,and changes of TNF-α,IL-8 and IL-10 were observed during the treatment.Results:The effective time of the observation group was significantly lower than that of the control group;the total effective rate of the observation group was 98.2%,which was significantly higher than that of the control group by 90.9%;the recurrence rate of adverse reactions in the observation group was also significantly lower than that of the control group;compared with the group before treatment,the difference was statistically significant in the 2 groups in hemodynamic indicators(P<0.05).After treatment,the difference was statistically significant in the blood rheology indexes of the observation group,compared with the control group,(all P<0.05);the levels of TNF-α,IL-8 and IL-10 were significantly lower than those in the group before treatment.Compared with the control group,the levels of TNF-α,IL-8 and IL-10 were significantly decreased in the observation group,and the differences were statistically significant(P<0.05).Conclusion:Danbai Granules combined with azithromycin in the treatment of chronic pelvic inflammatory disease may be by affecting the expression levels of TNF-α,IL-8 and IL-10 in the blood of patients to improve their uterine hemodynamic indicators,and ultimately improve treatment,reduce the recurrence rate and the incidence of adverse reactions.