β-内啡肽在小儿中枢神经系统感染中的作用及纳洛酮治疗效果观察

The Role of β-Endorphin in Children with Central Nervous System Infection and the Therapeutic Effect of Naloxone

总结β-内啡肽在小儿中枢神经系统感染中的作用并观察纳洛酮治疗效果。选取该院2017年1月~2018年12月收入的110例小儿中枢神经系统感染患儿为观察组,另选同期健康体检的110例正常儿童为对照组,对两组血浆及脑脊液中β-内啡肽进行测定和比较并利用Spearman相关性分析法分析β-内啡肽与脑水肿程度之间的相关性。随后利用随机数余数分组法将观察组110例患儿分为接受常规治疗的常规组及加用纳洛酮治疗的纳洛酮组各55例,对两组治疗效果进行对比。观察组血浆β-内啡肽、脑脊液β-内啡肽均高于对照组,差异有统计学意义(t=2.337、2.456,P<0.05);观察组内轻度脑水肿患儿血浆β-内啡肽、脑脊液β-内啡肽低于重度脑水肿患儿,差异有统计学意义(t=2.284、2.340,P<0.05);Spearman相关性分析结果提示,β-内啡肽与小儿中枢神经系统感染患儿脑水肿程度呈显著的正相关性(r=0.778,P<0.05);治疗前观察组内两个亚组血浆β-内啡肽、脑脊液β-内啡肽无明显差异(t=0.241、0.339,P>0.05),治疗后纳洛酮组均低于常规组,差异有统计学意义(t=1.077、1.021,P<0.05);治疗结束后观察组内纳洛酮不良反应发生率与常规组数值相当,无明显差异(x^2=0.184、0.278、0.000,P>0.05)。β-内啡肽与小儿中枢神经系统感染病情严重程度密切相关,而纳洛酮治疗效果更佳,值得加以推广。

To summarize the role ofβ-endorphin in children with central nervous system infection and observe the therapeutic effect of naloxone.110 children with central nervous system infection from January 2017 to December 2018 in the author’s hospital were selected as observation group and 110 normal children as control group.The levels of β-endorphin in plasma and cerebrospinal fluid were measured and compared between the two groups.Spearman correlation analysis was used to analyze the correlation between β-endorphin and the degree of brain edema.Subsequently,110 children in the observation group were divided into routine treatment group and naloxone plus naloxone group with 55 cases in each group by random number residual grouping method.The therapeutic effects of the two groups were compared.The levels of plasma β-endorphin and cerebrospinal fluid β-endorphin in the observation group were higher than those in the control group(t=2.337,2.456,P<0.05);the levels of plasma β-endorphin and cerebrospinal fluid β-endorphin in the observation group were lower than those in the severe group(t=2.284,2.340,P<0.05).Spearman correlation analysis showed that there was a significant positive correlation betweenβ-endorphin and brain edema in children with central nervous system infection(r=0.778,P<0.05).There was no significant difference in plasma β-endorphin and cerebrospinal fluid β-endorphin between the two subgroups before treatment(t=0.241,0.339,P>0.05).After treatment,naloxone group was lower than the routine group,and the difference was significant(t=1.077,1.021,P<0.05).The incidence of adverse reactions of naloxone in the observation group was similar to that in the conventional group(x^2=0.184,0.278,0.000,P>0.05).β-endorphin is closely related to the severity of central nervous system infection in children,and Naloxone has better therapeutic effect,which is worth popularizing.