摘要
The synergistic therapy of chemotherapy and photothermal therapy(PTT)has been reported as a promising antitumor strategy.To achieve effective combination therapy,developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very necessary.Herein,a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin(DOX)loading.We further designed PtPd-ethylene glycol(PEG)-folic acid(FA)-doxorubicin(DOX)nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active targeting.Moreover,excellent photoacoustic(PA)imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles’targeting effect.The in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor.
基金
This work was financially supported by the National Natural Science Foundation of China(Nos.31930067,31525009,31800797,and 31771096)
the National Key Research and Development Program of China(Nos.2017YFC1103502 and 2016YFA0201402)
the China Postdoctoral Science Foundation funded project(No.2018M631094)
the Postdoctoral Innovation Talents Support Program(No.BX20180207)
1·3·5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYGD18002).
