马来酸曲美布丁联合多潘立酮对胆汁反流性胃炎血清IL-6和VIP的影响

Effects of trimebutine maleate and domperidone on serum IL-6 and VIP in bile reflux gastritis

目的探讨马来酸曲美布丁与多潘立酮联合用药治疗胆汁反流性胃炎对患者血清中白介素-6(IL-6)、血管活性肠肽(VIP)水平的影响。方法选取2017年10月至2019年10月本院收治的胆汁反流性胃炎患者160例,随机分为研究组和对照组,每组80例。研究组给予奥美拉唑+铝碳酸镁+马来酸曲美布丁+多潘立酮治疗,对照组给予奥美拉唑+铝碳酸镁+多潘立酮治疗。比较两组用药前、用药后2周血清中IL-6、VIP水平及症状积分、症状改善情况。结果治疗2周后,两组症状积分、血清中IL-6、VIP水平均下降,且观察组低于对照组(P<0.05);观察组各项症状恢复时间短于对照组,差异有统计学意义(P<0.05)。结论马来酸曲美布丁联合多潘立酮治疗胆汁反流性胃炎疗效显著,能明显缓解患者临床症状,降低血清中IL-6、VIP水平,值得临床推广。

Objective To investigate the effect of combined treatment with trimebutine maleate and domperidone on bile reflux gastritis, the serum interleukin-6(IL-6) and vasoactive intestinal peptide(VIP) levels in patients. Methods 160 patients with bile reflux gastritis treated in our hospital from October 2017 to October 2019 were selected. They were randomly divided into study group and control group, with 80 cases in each group. The study group was treated with omeprazole+magnesium aluminum carbonate+trimebutine maleate+domperidone. The control group was treated with omeprazole+aluminum magnesium carbonate + domperidone. The serum IL-6, VIP level before and 2 weeks after medication, the symptom score and symptom improvement were compared between the two groups. Results After 2 weeks of treatment, the symptom scores, serum interleukin-6(IL-6) and vasoactive intestinal peptide(VIP) levels in the two groups all decreased, and the observation group was lower than the control group(P<0.05). The recovery time of various symptoms in the observation group was shorter than the control group, the difference was statistically significant(P<0.05). Conclusion The combination of trimebutine maleate and domperidone in the treatment of bile reflux gastritis has significant effect, which can alleviate the clinical symptoms of patients, reduce the serum levels of IL-6 and VIP, and is worthy of clinical promotion.