神经病靶酯酶的表达调控和生物功能

Expression Regulation and Biological Function of Neuropathy Target Esterase

神经病靶酯酶(neuropathy target esterase,NTE)能在有机磷酸酯类化合物的作用下发生“老化反应”,导致有机磷酸酯诱导的迟发性神经病(organophosphate induced delayed polyneuropathy,OPIDP)的产生。NTE由PNPLA6(patatin-like phospholipase domain containing 6)基因编码,在神经元分化的早期也起着至关重要的作用,PNPLA6基因沉默将抑制神经元的正常分化。除此之外,NTE还能够水解磷脂酰胆碱(phosphatidylcholine,PC)维持细胞膜的稳定性,并随着细胞周期的进程中而发生规律性的变化。NTE氨基末端的调节域具有环磷酸腺苷(cyclic adenosine monophosphate,cAMP)的结合位点,近年来cAMP/PKA/CREB通路被证实能够显著调控NTE的表达,其他参与调控的通路及分子也逐渐被人们所发现。文章就NTE的表达调控和生物功能展开综述。

Neuropathy target esterase(NTE)can cause an aging reaction under the action of organophosphate compounds,leading to the production of organophosphate induced delayed polyneuropathy(OPIDP).NTE and PNPLA6(patatin-like phospholipase domain containing 6)genes also play an important role in the early stage of neuronal differentiation.PNPLA gene silencing will inhibit the normal differentiation of neurons.In addition,NTE is also capable of hydrolyzing phosphatidylcholine(PC)to maintain the stability of the cell membrane and to change regularly as the cell cycle progresses.The NTE-terminal regulatory domain of NTE has a binding site for cyclic adenosine monophosphate(cAMP).In recent years,the cAMP/PKA/CREB pathway has been shown to significantly regulate the expression of NTE,and other pathways and molecules involved in regulation have gradually been discovered.This paper reviews the expression regulation and biological function of NTE.