慢性精神分裂症患者血清SOD、BDNF、PANSS量表评分及临床意义

Clinical significance of serum SOD,BDNF and scores of PANSS scale in patients with chronic schizophrenia

目的探讨慢性精神分裂症患者血清超氧化物歧化酶(SOD)、脑源性营养因子(BDNF)、阳性和阴性症状量表(PANSS)评分及临床意义,为患者的病情及预后评估提供指导。方法选取2018年3月—2020年3月安徽省芜湖市第四人民医院(以下简称“我院”)精神科收治的80例慢性精神分裂症患者作为观察组,另选取同期于我院体检的80例健康正常人作为对照组。采用酶联免疫吸附试验检测两组人群血清SOD、BDNF水平,采用PANSS评分评定精神病理症状。分析血清SOD、BDNF水平与PANSS评分相关性。结果观察组血清SOD水平高于对照组,BDNF水平低于对照组,差异有统计学意义(P<0.05)。观察组一般病理、阴性症状、阳性症状评分及总分高于对照组,差异有统计学意义(P<0.05)。血清SOD水平与阴性症状、阳性症状评分及总分呈正相关(r>0,P<0.05);血清BDNF水平与一般病理评分呈正相关(r>0,P<0.05),与PANSS阴性症状、阳性症状呈负相关(r<0,P<0.05)。结论慢性精神分裂症患者血清SOD水平、PANSS评分明显升高,BDNF水平明显下降,与疾病严重程度有一定相关性。检测上述指标有助于判断病情和评估预后。

Objective To study the clinical significance of serum superoxide dismutase(SOD),brain-derived nutrition factor(BDNF)and scores of positive and negative symptom scale(PANSS)scale in patients with chronic schizophrenia,and to provide guidance for patients′condition and prognosis evaluation.Methods From March 2018 to March 2020,80 patients with chronic schizophrenia admitted to the Department of Psychiatric of the Fourth People′s Hospital of Wuhu City,Anhui(hereinafter referred to as“our hospital”)were selected as the observation group,and 80 healthy normal people served who received physical examination in our hospital during the same period were selected as the control group.Enzyme-linked immunosorbent assay was used to detect serum SOD and BDNF levels in the two groups,and PANSS score was used to assess psychopathological symptoms.The correlation between serum SOD and BDNF levels and PANSS score were analyzed.Results The serum SOD level of the observation group was higher than that of the control group,while BDNF level was lower than that in the control group,and the differences were statistically significant(P<0.05).The general pathology,negative symptoms,positive symptoms scores and total scores of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).Serum SOD level was positively correlated with negative symptoms,positive symptom scores and total scores(r>0,P<0.05);serum BDNF level was positively correlated with general pathological scores(r>0,P<0.05),while negatively correlated with PANSS negative symptoms and positive symptoms(r<0,P<0.05).Conclusion The serum SOD level and PANSS score of patients with chronic schizophrenia are significantly increased,and the BDNF level is significantly decreased,which is related to the severity of the disease.The detection of the above indicators helps to judge the condition and assess the prognosis.