慢性肾脏病患者铁缺乏及铁代谢

Iron deficiency and iron metabolism in chronic kidney disease patients

慢性肾脏病患者常伴有不同程度的铁缺乏和铁代谢紊乱,铁调素、炎症、红细胞生成素、低氧诱导因子等参与上述过程。临床上将铁缺乏分为绝对性铁缺乏和功能性铁缺乏,铁调素、铁蛋白、转铁蛋白饱和度是评价和鉴别铁缺乏有效的指标。临床上合理选择和补充铁剂、降低铁调素水平、改善铁代谢紊乱对治疗慢性肾脏病铁缺乏非常重要。

Chronic kidney disease(CKD) patients are often accompanied by various degrees of iron deficiency and iron metabolism disorders;hepcidin, inflammation, erythropoietin and hypoxia-inducing factors are involved in the abnormalities. Iron deficiency can be classified into absolute iron deficiency and functional iron deficiency. Hepcidin, ferritin and transferrin saturation are useful markers to evaluate and diagnose iron deficiency. Clinically, rational use of iron supplements, reduction of hepcidin level, and improvement of iron metabolism are critical in the treatment of iron deficiency in CKD patients.