血栓通联合小牛血清去蛋白注射液对急性脑梗死患者血清S100B、MMP-9影响观察

Effect of Xueshuantong combined with calf serum deproteinized injection on serum S100B and MMP-9 in patients with acute cerebral infarction

探究血栓通联合小牛血清去蛋白注射液对急性脑梗死患者血清S100B、基质金属蛋白酶-9(MMP-9)的影响。选取2016年1月至2017年12月我院神经内科收治的112例急性脑梗死患者作为研究对象,按照随机数字表法分为观察组和对照组,每组各56例。对照组采用血栓通注射液治疗,观察组在对照组基础上联合小牛血清去蛋白注射液治疗。治疗2周,观察两组患者疗效,血清S100B、MMP-9变化,神经功能及安全性。观察组总有效率94.6%(53/56)明显高于对照组80.4%(45/56)(P<0.05)。治疗后,观察组血清S100B、MMP-9水平低于对照组(P<0.05);观察组NIHSS评分低于对照组,ADL评分高于对照组(P<0.05);两组患者肝肾功能比较无显著差异(P>0.05)。血栓通联合小牛血清去蛋白注射液治疗急性脑梗死患者疗效显著,可有效改善血清S100B、MMP-9水平,保护患者神经功能,安全可靠。

To explore the effect of Xueshuantong combined with calf serum deproteinized injection on serum S100B and matrix metalloproteinase-9(MMP-9)in patients with acute cerebral infarction.112 patients with acute cerebral infarction admitted to the Department of Neurology of our hospital from Jun 2016 to Dec 2017 were selected as the research subjects.They were divided into observation group and control group according to random number table method,with 56 cases in each group.The control group was treated with Xueshuantong injection,while the observation group was treated with deproteinized calf serum injection on the basis of the control group.After 2 weeks of treatment,the curative effect,changes of serum S100B and MMP-9,neurological function and safety of the two groups were observed.The total effective rate of the observation group was 94.6%(53/56),significantly higher than that of the control group,which was 80.4%(45/56)(P<0.05).After treatment,the serum levels of S100B and MMP-9 in the observation group were lower than those in the control group(P<0.05);the NIHSS score in the observation group was lower than that in the control group,and the ADL score was higher than that in the control group(P<0.05);there was no significant difference in liver and kidney function between the two groups(P>0.05).Xueshuantong combined with calf serum deproteinized injection has a significant effect on acute cerebral infarction patients.It can effectively improve the levels of serum S100B and MMP-9,protect the neurological function of patients,and is safe and reliable.