促炎细胞因子在特发性视神经炎发病机制中的作用

Recent advances in the role of proinflammatory cytokines in the pathogenesis of idiopathic optic neuritis

视神经炎(ON)是由各种原因引起的视神经炎性病变,是中青年人最易罹患的致盲性视神经疾病。特发性视神经炎(ION)以经典多发性硬化相关性视神经炎(MS-ON)和视神经脊髓炎相关性视神经炎(NMO-ON)最常见。ION起病急、易复发,视功能损害较重,炎症是ION的一个重要的发生机制。细胞因子是一类具有调控免疫系统作用的小分子可溶性多肽的统称,促炎细胞因子(proinflammatory cytokines)通过介导炎症反应、参与免疫应答,在ION发病机制中的作用引起越来越广泛的关注。本文通过查阅国内外相关文献,就促炎细胞因子在ION发病机制中的作用最新研究作一综述,以推进ION发病机制和诊疗的深入研究。

Optic neuritis(ON),which is the blinding optic nerve diseases that the young and middle-aged population are most susceptible to,is an optic neuropathy caused by various factors.Idiopathic optic neuritis(ION)occurs most frequently asmultiple sclerosis related optic neuritis(MS-ON)and neuromyelitis optica related optic neuritis(NMO-ON).ION has the characteristics of acute onset,easy recurrence,and serious dysfunction.Inflammation is an important mechanism of ION.By mediating inflammatory responses and participating in immune responses,proinflammatory cytokines,as one of cytokines which is a general term for a class of small molecule soluble peptides that regulate the immune system,have caused widespread concern in the pathogenesis of ION.This article reviews and discusses researches on the pathogenesis of proinflammatory cytokines-mediated ION at home and abroad in an effort to promote an in-depth study of the pathogenesis,diagnosis and treatment of ION.