SARS-CoV-2经结膜感染与结膜炎研究述评

A review of research of conjunctiva transmission and conjunctivitis of SARS-CoV-2

当前因新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)引起的新型冠状病毒感染的肺炎(corona virus disease 2019,COVID-19)在我国传播乃至全球爆发,快速蔓延至世界各国,严重威胁世界人民的生命安全与健康。由于特效药物的缺失,积极预防仍是目前抵御COVID-19的有效方法。临床观察发现COVID-19患者可并发结膜炎,动物实验也证实结膜是SARS-CoV-2传播的途径之一。但已有的研究结果存在明显差异性,SARS-CoV-2感染与结膜炎发生的关系也未阐明。所以本文结合目前最新的研究和报道,通过各项分析研究结果,进一步阐述SARS-CoV-2感染与结膜及结膜炎的关系,探讨结膜作为SARS-CoV-2传播途径之一对于该病防护的意义,为该病与眼表关系的研究和临床判读提供帮助。

Corona virus disease 2019(COVID-19)epidemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has broken out with a vengeance,seriously threatening the global public health security.Due to the lack of specific effective drugs,effective and positive protective measures are still the most effective ways to prevent COVID-19.Clinical studies had shown that patients with COVID-19 might develop conjunctivitis symptoms.An animal experiment had also confirmed that the conjunctiva was one of the routes of SARS-CoV-2 transmission.However,current studies have gotten different or even contrary conclusions,and the relationship between SARS-CoV-2 infection and the occurrence of conjunctivitis has not been elucidated.Therefore,this article combines the latest clinical and animal studies to further elaborate the relationship between SARS-CoV-2 conjunctivatransmission and conjunctivitis,and explore the significance of conjunctiva transmission of SARS-CoV-2 protection.