重组人促红素注射液对长期血液透析患者血液生化指标及心脏功能的影响

Effects of recombinant human erythropoietin injection on blood biochemical indexes and cardiac function in patients with long-term hemodialysis

目的探究重组人促红素注射液对长期血液透析患者血液生化指标及心脏功能的影响。方法抽取2016年4月至2018年9月于许昌市中心医院诊治的200例慢性肾功能衰竭患者进行研究,根据治疗方法分为观察组(96例)和对照组(104例)。对照组给予常规血液透析治疗,观察组在对照组治疗基础上加用重组人促红素注射液。治疗3个月,观察两组血液透析指标(尿素清除指数、血细胞压积)、肾功能(尿蛋白排泄率、血肌酐)、心脏功能[心排血量(CO)、左室射血分数(LVEF)、室间隔舒张末期厚度(LVST)]、营养状态[血红蛋白(Hb)、血清白蛋白(ALB)、非内瘘上肢肱三头肌皮下脂肪厚度(TSF)]及生活质量(角色功能、躯体功能、情绪功能、社会功能及总分)。结果治疗后,观察组尿素清除指数低于对照组,血细胞压积高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组尿蛋白排泄率、血肌酐水平低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组CO、LVEF水平高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组Hb、ALB、TSF水平均高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组角色功能、躯体功能、情绪功能、社会功能及总分得分均高于对照组,差异有统计学意义(P<0.05)。结论重组人促红素注射液有利于改善长期血液透析患者血液生化指标、肾功能及心脏功能,提高其生活质量。

Objective To investigate the effects of recombinant human erythropoietin injection on blood biochemical parameters and cardiac function in patients with long-term hemodialysis.Methods A total of 200 patients with chronic renal failure diagnosed and treated in Xuchang Central Hospital from April 2016 to September 2018 were enrolled. According to treatment methods, they were divided into observation group (96 cases) and control group (104 cases). The control group was given conventional hemodialysis treatment, and the observation group was treated by recombinant human erythropoietin injection on the basis of treatment of the control group. After 3 months of treatment, the hemodialysis indicators (urea clearance index, hematocrit), renal function (urinary protein excretion rate, blood creatinine), cardiac function assessed by cardiac output (CO), left ventricular ejection fraction ( LVEF), intel-ventricular scptum end-diastolic thickness (LVST), nutritional status evaluated by hemoglobin (Hb), serum albumin (ALB), non-endosteal upper limb triceps subcutaneous fat thickness (TSF), and quality of life, assessed by role function, body function, emotional function, social function and total score, of the two groups were observed.Results After treatment, the urea clearance index of the observation group was lower than that of the control group, and the hematocrit was higher than that of the control group (P<0.05). After treatment, the urine protein excretion rate and serum creatinine level in the observation group were lower than those in the control group (P<0.05). After treatment, the levels of CO and LVEF in the observation group were higher than those in the control group (P<0.05). After treatment, the levels of Hb, ALB, and TSF in the observation group were higher than those in the control group (P<0.05). After treatment, the role function, physical function, emotional function, social function, and total score of the observation group were higher than those of the control group (P<0.05).Conclusions Recombinant human erythropoietin injection is beneficial to improving the blood biochemical indexes, renal function and heart function in patients with long-term hemodialysis, and it can promote their quality of life.