血清midkine、SIL-2R及HMGB-1水平与甲状腺癌发生发展的关系

The relationship between serum levels of midkine,SIL-2R and HMGB-1 and the development of thyroid cancer

目的探讨血清中期因子(midkine)、白细胞介素-2受体(SIL-2R)、高迁移率族蛋白B1(HMGB1)与甲状腺癌发生发展的关系。方法选取我院2010年1月至2013年12月确诊的90例甲状腺癌患者、90例结节性甲状腺肿患者(良性组)、90例健康对象作为对照组,检测三组的血清midkine、SIL-2R及HMGB-1水平,并按照甲状腺癌的临床特征进行分层分析。结果甲状腺癌组患者的血清midkine、SIL-2R及HMGB-1水平显著的高于良性组、对照组,差异具有统计学意义(P<0.05);血清midkine、SIL-2R及HMGB-1水平在良性组与对照组间比较,差异无统计学意义(P>0.05);不同TNM分期、是否发生淋巴结转移的甲状腺癌患者血清midkine水平差异具有统计学意义(P<0.05);不同TNM分期的甲状腺癌患者血清SIL-2R水平差异具有统计学意义(P<0.05);不同TNM分期、是否发生淋巴结转移的甲状腺癌患者血清HMGB-1水平差异具有统计学意义(P<0.05);不同5年预后结局患者的血清midkine、SIL-2R及HMGB-1水平组间比较,差异无统计学意义(P>0.05)。结论甲状腺患者血清midkine、SIL-2R及HMGB-1水平均增高,并且与患者疾病发展具有显著的相关性。

Objective To investigate the relationship between serum midkine,interleukin-2 receptor(SIL-2R),high mobility group box protein B1(HMGB1)and the development of thyroid cancer.Methods Ninty patients with thyroid cancer(malignant group),90 patients with nodular goiter(benign group),and 90 healthy subjects were selected as control group from January 2010 to December 2013.The serum of the three groups were tested.The levels of midkine,SIL-2R and HMGB-1 were analyzed hierarchically according to the clinical features of thyroid cancer.Results Serum midkine,SIL-2R and HMGB-1 levels were significantly higher in the malignant group than in the benign group and the control group(P<0.05).Serum midkine,SIL-2R and HMGB-1 levels were in the benign group.There was no significant difference between the two groups(P>0.05).There were significant differences in serum midkine levels between thyroid cancer patients with different TNM stages and lymph node metastasis(P<0.05).There was significant difference in serum SIL-2R levels among different TNM stages(P<0.05).The difference of serum HMGB-1 level in patients with thyroid cancer with different TNM stage and lymph node metastasis was statistically significant(P<0.05);There were no significant differences in serum midkine,SIL-2R and HMGB-1 levels between the 5 years of prognosis outcomes(P>0.05).Conclusion Serum midkine,SIL-2R and HMGB-1 levels were elevated in thyroid patients and were significantly associated with disease progression in patients.