血清7-AABs、CEA、ProGRP水平变化与肺癌患者预后的关系研究

Study on the relationship between serum levels of 7-AABs,CEA and ProGRP and prognosis of lung cancer patients

目的观察肺癌患者血清7种自身免疫性抗体(7-AABs)、癌胚抗原(CEA)、胃泌素释放肽前体(ProGRP)水平变化,并分析其临床意义。方法选取2015年8月-2017年8月在我院接受治疗的肺癌患者为研究对象,同时选取同期在我院接受检查的肺囊肿患者为对照。观察两组患者7-AABs、CEA、ProGRP水平的差异,比较不同预后的肺癌患者7-AABs、CEA、ProGRP水平的差异。结果观察组患者的抑癌基因产物p53、PGP 9.5、SOX2、GAGE7、ATP结合RNA解旋酶GBU4-5、MAGEA1、CAGE水平高于对照组患者(P<0.001);观察组患者的CEA、ProGRP水平分别为85.23±4.24μg/L、46.79±5.08pg/ml,高于对照组患者(P<0.001);存活组患者的抑癌基因产物p53、PGP 9.5、SOX2、GAGE7、ATP结合RNA解旋酶GBU4-5、MAG EA1、CAGE水平低于死亡组患者(P<0.001);存活组患者的CEA、ProGRP水平分别为18.92±2.35μg/L、30.25±4.12pg/ml,明显低于死亡组(t=-89.555、-17.447,P<0.001)。相关分析法结果显示,p53、ATP结合RNA解旋酶GBU4-5与患者预后密切相关(r=0.342、0.413,P<0.05)。结论肺癌患者血清7-AABs、CEA、ProGRP水平较高,且与患者的预后密切相关。

Objective The levels of seven autoimmune antibodies(7-AABs),carcinoembryonic antigen(CEA)and gastrin releasing peptide precursor(ProGRP)in lung cancer patients were detected and their clinical significance was analyzed.Methods Lung cancer patients who were treated in our hospital from August 2015 to August 2017 were selected as the study subjects,and lung cyst patients who were examined in our hospital during the same period were selected as the control group.The difference of 7-AABs,CEA and ProGRP levels between the two groups was observed.The differences of 7-AABs,CEA and ProGRP levels in lung cancer patients with different clinical characteristics and prognosis were compared.The factors influencing 7-AABs,CEA and ProGRP levels in lung cancer patients were analyzed.Results The levels of p53,PGP 9.5,SOX2,GAGE7,ATP-binding RNA helicase GBU4-5,MAGEA1 and CAGE in the observation group were higher than those in the control group(P<0.001);the levels of CEA and ProGRP in the observation group were 85.23±4.24 ug/L and 46.79±5.08pg/ml,respectively,higher than those in the control group(P<0.001);the levels of p53,PGP 9.5,SOX2,GAGE7 and AT in the survival group were higher than those in the control group(P<0.001).The levels of P-binding RNA helicase GBU4-5,MAGEA1 and CAGE in survival group were lower than those in death group(P<0.001),and the levels of CEA and ProGRP in survival group were 18.92±2.35 ug/L and 30.25±4.12 pg/ml,respectively,which were significantly lower than those in death group(t=-89.555,-17.447,P<0.001).Conclusion The serum levels of 7-AABs,CEA and ProGRP in patients with lung cancer are higher,and they are closely related to the prognosis of patients.