血清STIP1、SMRP、TK1在卵巢癌患者中的表达及其对预后的判定价值

Expression and prognostic value of serum STIP1,SMRP and TK1 in patients with ovarian cancer

目的:分析血清磷酸化应激诱导蛋白1(STIP1)、可溶性间皮素相关蛋白(SMRP)、细胞质胸苷激酶1(TK1)在卵巢癌患者中的表达及其对预后判定的价值。方法:抽取2014年6月至2017年2月郑州大学附属洛阳中心医院84例卵巢癌患者与同期64例健康体检者的临床资料进行回顾性分析。将卵巢癌患者作为卵巢癌组,健康体检者作为对照组。检测比较卵巢癌组和健康体检者,卵巢癌组不同临床病理特征、不同预后患者血清STIP1、SMRP、TK1表达及血清各指标不同表达卵巢癌患者的生存情况。结果:卵巢癌组血清STIP1、SMRP、TK1表达高于对照组(P<0.05);组织分化程度为低分化、FIGO分期Ⅲ~Ⅳ期、有淋巴结转移卵巢癌患者血清STIP1、SMRP、TK1表达高于组织分化程度为中高分化、FIGO分期Ⅰ~Ⅱ期、无淋巴结转移患者(P<0.05);3年死亡卵巢癌患者血清STIP1、SMRP、TK1表达高于3年生存患者(P<0.05);血清STIP1、SMRP、TK1低表达卵巢癌患者生存率高于高表达患者(P<0.05)。结论:血清STIP1、SMRP、TK1在卵巢癌患者中过度表达,与FIGO分期、组织分化程度、淋巴结转移存在一定相关性,三者联合有望成为卵巢癌预后评估的有效手段。

Objective To analyze the expression and prognostic value of serum phosphorylation stress-induced protein 1(STIP1),soluble mesothelin-related protein(SMRP),and cytoplasmic thymidine kinase 1(TK1)in patients with ovarian cancer.Methods The clinical data of 84 patients with ovarian cancer in Luoyang Central Hospital Affiliated to Zhengzhou University from June 2014 to February 2017 and 64 healthy medical examiners during the same period were retrospectively analyzed.Patients with ovarian cancer were included in the ovarian cancer group,and healthy subjects were used in the control group.The expressions of STIP1,SMRP,and TK1 in the two groups and ovarian cancer patients with different clinicopathological characteristics and patients with different prognosis,and the survival of ovarian cancer patients with different serum indicators were analyzed and compared.Results The expression of STIP1,SMRP and TK1 in ovarian cancer group was higher than that in control group(P<0.05);the expression of serum STIP1,SMRP,and TK1 in patients with poorly differentiated,FIGO stage III-IV,and lymph node metastatic ovarian cancer were higher than those in patients with moderate to high differentiation,FIGO stageⅠ-Ⅱ,and no lymph node metastasis(P<0.05);the expressions of STIP1,SMRP,and TK1 in serum of patients with ovarian cancer who died in 3 years were higher than those of patients who survived in 3 years(P<0.05);the survival rates of patients with low expression of STIP1,SMRP and TK1 in ovarian cancer were higher than those in patients with high expression(P<0.05).Conclusions Serum STIP1,SMRP,and TK1 are over-expressed in ovarian cancer patients,and they are related to FIGO stage,tissue differentiation,and lymph node metastasis,the combination of the three is expected to be an effective method for prognostic evaluation of ovarian cancer.