羟氯喹联合米诺环素治疗玫瑰痤疮的效果观察

Efficacy of hydroxychloroquine combined with minocycline on acne rosacea

目的:观察羟氯喹联合米诺环素治疗玫瑰痤疮的临床效果。方法:抽取2016年2月至2019年5月于驻马店市第一人民医院接受治疗的102例玫瑰痤疮患者为受试对象,依据随机数字表分为观察组与对照组,每组51例。对照组给予羟氯喹治疗,观察组在其基础上联合米诺环素进行治疗。比较两组治疗前及治疗6、12周后的临床症状评分,评估其短期内(12周内)临床疗效,并记录其治疗前后的皮肤屏障功能[红斑指数(EI)、角质层含水量、经皮水分丢失(TEWL)]及治疗过程中的不良反应发生情况。结果:治疗6、12周后,两组患者临床症状评分较治疗前均降低(P均<0.05),且观察组低于对照组(P<0.05)。治疗12周后,观察组总有效率为94.12%(48/51),对照组为80.39%(41/51),差异有统计学意义(P<0.05)。治疗12周后,两组患者角质层含水量较治疗前均上升(P均<0.05),且观察组高于对照组(P<0.05);而EI、TEWL较治疗前均下降(P均<0.05),且观察组低于对照组(P<0.05)。治疗过程中,两组相关不良反应发生率比较差异未见统计学意义(P>0.05)。结论:羟氯喹联合米诺环素可有效改善玫瑰痤疮患者临床症状,提高临床疗效。

Objective To observe the efficacy of hydroxychloroquine combined with minocycline in the treatment of acne rosacea.Methods A total of 102 patients with acne rosacea who were treated in Zhumadian First People’s Hospital from February 2016 to May 2019 were selected as subjects,and they were divided into observation group and control group according to the random number table,with 51 cases in each group.Control group was treated with hydroxychloroquine,and observation group was combined with minocycline on this basis.The clinical symptoms scores before treatment and after 6 weeks and 12 weeks of treatment were compared between the two groups,and the short-term(within 12 weeks)clinical efficacy was evaluated,and the skin barrier function,such as erythema index(EI),water content of stratum corneum,transepidermal water loss(TEWL)and the occurrence of adverse reactions during treatment were recorded.Results After 6 weeks and 12 weeks of treatment,the clinical symptoms scores in the two groups were significantly decreased compared with those before treatment(all P<0.05),and the scores in observation group were significantly lower than those in control group(P<0.05).After 12 weeks of treatment,the total effective rate was 94.12%(48/51)in observation group and was 80.39%(41/51)in control group(P<0.05).After 12 weeks of treatment,the moisture content of stratum corneum in the two groups was increased significantly compared with that before treatment(P<0.05),and the moisture content in observation group was significantly higher than that in control group(P<0.05).The EI and TEWL were significantly decreased compared with those before treatment(P<0.05),and the two indexes in observation group were significantly lower than those in control group(P<0.05).During treatment,there were no statistically significant differences in the incidences of related adverse reactions between the two groups(P>0.05).Conclusions Hydroxychloroquine combined with minocycline can effectively improve the clinical symptoms and enhance the clinical efficacy of patients with acne rosacea.