不适合手术的原发性肝癌的综合治疗进展

Progress in multimodality therapy for primary hepatocellular carcinoma unsuitable for surgery

目前手术切除仍然是治疗原发性肝癌的首选,但由于早期肝癌缺乏典型临床表现,一旦出现症状和体征疾病多已进入中晚期,手术治疗效果不佳,对于此部分病人采用介入、消融、靶向、免疫、放化疗等综合治疗。本文参考相关资料,探讨不适合手术的原发性肝癌的综合治疗进展。

At present,surgical resection is still the first choice for the treatment of primary hepatocellular carci⁃noma.However,due to the lack of typical clinical manifestations in early hepatocellular carcinoma,most cases have entered the advanced stage once symptoms and signs appear,which results in a poor surgical outcome.For these pa⁃tients,multimodality therapy including interventional therapy,ablation therapy,targeted therapy,immunotherapy,and radiochemotherapy is adopted.With reference to relevant data,this article reviews the progress in multimodality therapy for primary hepatocellular carcinoma that is unsuitable for surgery.