2型糖尿病并发冠心病患者血清C1q肿瘤坏死因子相关蛋白12浓度的临床意义

Clinical significance of serum concentration of C1q tumor necrosis factor-associated protein 12 in patients with type 2 diabetes mellitus combined with coronary heart disease

目的探讨2型糖尿病并发冠状动脉粥样硬化性心脏病(冠心病)患者血清C1q肿瘤坏死因子相关蛋白12(C1q tumor necrosis factor-associated protein 12,CTRP12)浓度的临床意义。方法选取2017年10月至2018年9月北京中医药大学东方医院收治的2型糖尿病并发冠心病患者60例作为研究组,选取同时期来我院检查的健康人群60名作为对照组。观察两组研究对象血清CTRP12、白细胞介素(interleckin,IL)-6、IL-10等因子浓度的差异,并且分析血清CTRP12浓度与患者生化指标的相关性。结果研究组患者血清CTRP12浓度[(2.7±0.9)ng/mL vs.(1.0±0.6)ng/mL,t=12.174,P<0.05]明显低于对照组,血清IL-6[(10.6±4.6)μg/L vs.(5.4±3.2)μg/L,t=7.188,P<0.05]、IL-10[(41.7±4.3)μg/L vs.(26.3±3.1)μg/L,t=22.503,P<0.05]浓度明显高于对照组,差异有统计学意义。Pearson相关分析结果显示,研究组患者血清CTRP12浓度与肥胖及血糖、胰岛素、血脂浓度有明显的相关性(P<0.05)。严重冠心病组患者血清CTRP12浓度明显低于轻度及中度冠心病组患者,血清IL-6、IL-10浓度明显高于轻度及中度冠心病组患者,差异有统计学意义(P<0.05)。结论2型糖尿病并发冠心病患者血清CTRP12浓度下降,且随着冠心病严重程度增加而降低。

Objectives To investigate the clinical significance of serum concentration of Clq tumor necrosis factorassociated protein 12(CTRP12)in patients with type 2 diabetes mellitus(T2 DM)combined with coronary heart disease.Methods From October 2017 to September 2018 in Beijing University of Traditional Chinese Medicine Oriental Hospital,60 patients with T2 DM combined with coronary heart disease were selected as study group.At the same period,60 healthy physical examination people in our hospital were selected as control group.Serum concentrations of CTRP12 and interleckin(IL)-6,IL-10 were compared between the two groups.Correlations between serum concentrations of CTRP12 with biochemical indexes in the patients were analyzed.Results Serum concentrations of CTRP12 in study group was significantly lower than that in control group[(2.7±0.9)ng/mL vs.(1.0±0.6)ng/mL,t=12.174.P<0.05],serum concentrations of IL-6[(10.6±4.6)μg/L vs.(5.4±3.2)μg/L,t=7.188,P<0.05],IL-10[(41.7±4.3)μg/L vs.(26.3±3.1)μg/L,t=22.503.P<0.05]were significantly higher than those in control group.Serum concentration of CTRP12 correlated with obesity,serum concentrations of blood glucose,insulin,and blood lipid in patients with T2 DM combined with coronary heart disease.Serum concentration of CTRP12 in patients with severe coronary heart disease was significantly lower than that in patients with mild and moderate coronary heart disease(P<0.05).Serum concentrations of IL-6,IL-10 were significantly higher in patients with severe coronar yheart disease than those in patients with mild and moderate coronary heart disease(P<0.05).Conclusions The indexes of CTRP12,IL-6,and IL-10 are close-1 y related to patients with T2 DM combined with coronary heart disease.