促炎症消退介质通过调节免疫细胞促进炎症消退的机制研究进展

Research progress on the mechanism of pro-inflammatory regression mediators promoting inflammation regression by regulating immune cells

炎症反应是一种有效的宿主防御机制,以消除感染部位的病原体;而炎症的消退阶段主要是维持组织内的稳态环境。促炎症消退介质(SPMs)是内源性抗炎分子,在减轻过度组织损伤和慢性炎症中起着重要作用。本文就SPMs在炎症部位与免疫细胞的相互作用进行综述,通过回顾相关文献发现,SPMs调节先天和适应性免疫系统的组成部分包括中性粒细胞、巨噬细胞、固有淋巴细胞、自然杀伤细胞和T细胞等。

Inflammatory response is an effective host defense mechanism to eliminate pathogens at the site of infection.The regression phase of inflammation mainly maintains the stable environment in tissues.Pro-inflammatory regression mediators(SPMs)are endogenous anti-inflammatory molecules,which play an important role in reducing excessive tissue damage and chronic inflammation.This paper reviews the interaction between SPMs and immune cells in inflammatory sites.By reviewing the relevant literature,it was found that SPMs regulate the components of innate and adaptive immune system,including neutrophils,macrophages,innate lymphocytes,natural killer cells and T cells.