摘要
甘遂烷型三萜是以6个异戊二烯单元为基本母核的四环三萜类化合物。目前发现的天然来源的甘遂烷型三萜类虽然数量较少,但是化合物结构多样,如apo-型、侧链呈直链型及侧链成环型;药理活性广泛,如细胞毒、抗炎、抗氧化及抗疟原虫等。该文综述了近十年该类三萜化合物的植物来源、化学结构及药理活性,并对该类化合物的未来研究探索进行了讨论与展望。
The tirucallane-type triterpenoids, composed of six isoprene units, belong to a group of tetracyclic triterpenoids. Although the naturally-derived tirucallane-type triterpenoids were found in a small amount, the kind of compounds showed various structures, which consist of apo-type, linear said-chain-type and cyclolike said-chain-type and broad bioactivities, such as cytotoxicity, anti-inflammation, antioxidation and anti-plasmin, etc. This paper summarized origins, structures and bioactivities of tirucallane-type triterpenoids in recent ten years. The future research and exploration of tirucallane-type triterpenoids were discussed and prospected.
作者
谢军
李常康
付佳
王洪庆
李保明
陈若芸
康洁
XIE Jun;LI Chang-kang;FU Jia;WANG Hong-qing;LI Bao-ming;CHEN Ruo-yun;KANG Jie(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2020年第15期3617-3630,共14页
China Journal of Chinese Materia Medica
基金
中国医学科学院医学与健康科技创新工程(CIFMS)项目(2016-I2M-1-010)
国家“重大新药创制”科技重大专项(2018ZX09711-001-001-001,2018ZX09711-001-001-003)。
关键词
甘遂烷型三萜
植物来源
化学结构
药理活性
tirucallane-type triterpenoids
origin
chemical structure
pharmacological activity
