老年初诊2型糖尿病应用门冬胰岛素30联合二甲双胍的临床治疗效果

Clinical efficacy of insulin aspartate 30 combined with metformin in elderly patients newly diagnosed with type 2 diabetes mellitus

目的探讨老年初诊2型糖尿病应用门冬胰岛素30联合二甲双胍的临床治疗效果。方法选取2017年3月—2019年3月,在北京朝阳糖尿病医院接受治疗的老年初诊2型糖尿病患者140例,作为研究对象。将患者分为A组与B组,其中A组70例,采用门冬胰岛素30治疗方法;B1组70例,应用门冬胰岛素30联合二甲双胍治疗方法2组患者的基线资料比较差异无统计学意义(P>0.05)。同时为了进一步验证2组患者门冬胰岛素30联合二甲双胍是双药治疗不同用量的变化,选取2组中病情较重的患者各10名参与到“不同剂量的对比”,A1组(同上),试验B1组在常规剂量的基础上提高日用量实验来实现更好的治疗效果。结果A组治疗后糖化血红蛋白、空腹血糖、餐后2 h血糖、餐后2 h甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白与B组比较,差异有统计学意义(P<0.05)。A组患者低血糖发生次数高于B组,组间比较差异有统计学意义(P<0.05)。在2组加重剂量B1组加重剂量后在血糖、血脂的控制上优于A1组。结论老年初诊2型糖尿病临床治疗方面,应用门冬胰岛素30联合二甲双胍治疗,可以控制患者血糖,也能够进一步促使血糖发生次数的减少。同时对于病情较重的患者在根据其体质、病情加重剂量临床效果更佳。

Objective To investigate the clinical efficacy of insulin 30 plus metformin in the treatment of type 2 diabetes mellitus(T2DM)in the elderly.Methods 140 elderly patients with newly diagnosed type 2 diabetes who were treated in our hospital from March 2017 to March 2019 were selected as the research objects.The patients were divided into group A and Group B,of which 70 patients in group A were treated with asparagine 30.70 patients in group B were treated with insulin 30 and metformin.There was no statistically significant difference in baseline data between the two groups(P>0.05),so comparison could be made.At the same time,in order to further verify that the combination of insulin 30 and metformin in the two groups was the change of different dosage of the two groups of patients,10 patients with severe disease in the two groups were selected to participate in the"comparison of different doses"experiment,group A1 was the same as above,and the daily dosage of group B1 was increased on the basis of the conventional dose to achieve better treatment effect.The changes of body related indexes before and after treatment and the times of hypoglycemia during treatment were observed.Results There were statistically significant differences between group A and Group B in HbA1c,fasting blood glucose,blood glucose and triglyceride total cholesterol at 2 h,high-density lipoprotein and low-density lipoprotein after treatment(P<0.05).The incidence of hypoglycemia in group A was higher than that in group B,and the difference between groups was statistically significant(P<0.05).The total incidence of hypoglycemia in group A wassignificantly higher than that in group B,with significant differences among groups.According to the data of this study,the incidence of hypoglycemia was significantly lower in elderly patients with newly diagnosed type 2 diabetes treated with insulin 30 plus metformin than that treated with insulin 30.The control of blood glucose and blood lipid in group B1 was better than that in group A1.Conclusion In the clinical treatment of type 2 diabetes in the elderly,the application of insulin 30 in combination with metformin can control the patient's blood glucose and further reduce the incidence of blood glucose.At the same time,the clinical effect is better for the patients with severe illness according to their constitution and the aggravating dose of illness.