51例肝细胞癌患者MSCT扫描征象及与其组织VEGF表达水平的相关性

Correlation analysis between MSCT scan signs and expression of VEGF in 51 patients with hepatocellular carcinoma

目的分析肝细胞癌(HCC)患者多层螺旋CT(MSCT)扫描征象及与其组织血管内皮生长因子(VEGF)表达水平的相关性。方法回顾性分析2015年4月至2018年12月本院收治的51例HCC患者,比较HCC组织与癌旁组织VEGF阳性率、微血管密度(MVD)水平,HCC组织VEGF阳性与阴性患者MVD水平,MSCT不同扫描征象患者血管生成指标水平,并分析MSCT扫描征象与VEGF、MVD的相关性。结果HCC组织VEGF阳性率(80.39%)高于癌旁组织(23.53%),MVD大于癌旁组织(P<0.05);HCC组织VEGF阳性患者MVD大于VEGF阴性患者(P<0.05);MSCT扫描病灶>5 cm与≤5 cm患者VEGF阳性率、MVD比较差异无统计学意义(P>0.05);假包膜无/欠完整患者VEGF阳性率、MVD高于完整患者,高危侵袭患者VEGF阳性率、MVD大于低危患者,动脉供血型患者VEGF阳性率、MVD大于双重供血、少供血型患者(P<0.05);MSCT扫描假包膜无/欠完整、高危侵袭性、动脉供血型、双重供血型与VEGF、MVD呈正相关,少供血型与VEGF、MVD呈负相关(P<0.05)。结论MSCT扫描能准确评估HCC病灶大小、是否存在假包膜情况、侵袭转移情况、强化类型等,假包膜无/欠完整、高危侵袭性、动脉供血型、双重供血型与VEGF、MVD呈正相关,少供血型与VEGF、MVD呈负相关,这可为肿瘤新生血管情况评估提供一种新的快速、简便、无创检查手段,为HCC诊断及预后评估提供参考。

Objective To analyze the multi-slice spiral CT(MSCT)scan signs and the expression of vascular endothelial growth factor(VEGF)in hepatocellular carcinoma(HCC)patients.Methods A total of 51 patients with HCC admitted to our hospital from April 2015 to December 2018 were enrolled.The VEGF positive rate,microvessel density(MVD)level,HCC VEGF positive and negative MVD levels,and MSCT were compared between HCC and paracancerous tissues.The level of angiogenesis index was scanned and the association between MSCT scan signs and VEGF and MVD was analyzed.Results The positive rate of VEGF and MVD in HCC tissues were higher than that in adjacent tissues(P<0.05);MVD in patients with VEGF positive HCC was higher than that in patients with VEGF negative(P<0.05);There was no significant difference in the positive rate of VEGF and MVD between patients with lesions>5 cm and≤5 cm(P>0.05).The VEGF positive rate and MVD in patients with pseudocapsule without/incomplete were higher than those in patients with intact capsule;the VEGF positive rate and MVD in patients with high risk invasion were higher than those in patients with low risk;the VEGF positive rate and MVD in arterial blood supply were higher than those in patients with dual supply and insufficient blood supply(P<0.05);MSCT scan showed that false capsule without/incomplete,high risk of invasion,arterial blood supply and double supply were positively correlated with VEGF and MVD,while less blood supply was negatively correlated with VEGF and MVD(P<0.05).Conclusions MSCT scan can accurately evaluate the size of HCC lesions,the presence of false capsule,invasion and metastasis,enhancement type,etc.No/incomplete pseudocapsule,high-risk invasion,arterial blood supply and dual supply are positively correlated with VEGF and MVD,while less blood supply is negatively correlated with VEGF and MVD.This can pro-vide a new rapid,simple and non-invasive examination method for the evaluation of tumor neovascularization and diagnosis and prognosis for HCC.