甲氨蝶呤用于儿童特应性皮炎的治疗效果评估

Therapeutic Effects of Methotrexate in Treating Childhood Atopic Dermatitis

目的评估甲氨蝶呤治疗中国儿童特应性皮炎的安全性和有效性。方法回顾性地收集2010年1月—2018年12月期间在重庆市中医院皮肤科门诊诊断为特应性皮炎,并使用甲氨蝶呤治疗的78例儿童的信息,记录治疗过程中的不良反应,比较治疗3个月和6个月后的疗效。结果所有患者的研究者总体评分(IGA)均为3~4,并且在接受甲氨蝶呤治疗前接受了全身系统性治疗。治疗3个月和6个月后,患儿的IGA评分交基线水平显著降低。在治疗过程中,有34.62%的患儿出现了轻微的不良反应,但都没有严重的不良反应。使用甲氨蝶呤治疗前,使用糖皮质激素治疗的患儿更容易取得良好效果。结论甲氨蝶呤是治疗中重度儿童特应性皮炎的安全和有效药物。

Objective In order to evaluate the safety and efficacy of methotrexate in treating Chinese children with atopic dermatitis.Methods A total of 78 children who were diagnosed with atopic dermatitis in the dermatology clinic at Chongqing traditional Chinese medicine hospital from January 2010 to December 2018 and treated with methotrexate was retrospectively collected.Side effects during treatment were documented.The efficacy of methotrexate treatment after three months and six months was compared.Results All patients had an IGA score of three to four and received systemic treatment before receiving methotrexate.After three months and six months of treatment,the children’s IGA scores were significantly lower than the baseline level.During the treatment,34.62%of the children had mild side effects,but there were no serious side effects.Children treated with glucocorticoids were more likely to achieve good results before treatment with methotrexate.Conclusion Methotrexate is a safe and effective drug for the treatment of atopic dermatitis in moderate to severe children.