调节性T细胞与卵巢癌肿瘤免疫的相关研究进展

Research Progress of Regulatory T Cells and Tumor Immunity of Ovarian Cancer

调节性T细胞(Treg)是一类具有免疫调节功能的特殊T细胞亚群,其中以CD4+CD25+Treg细胞亚型研究最为广泛,其主要作用为调节机体的免疫耐受功能。其能够通过直接接触的方式抑制CD8+和CD4+效应T细胞的活化和增殖,进而阻止自身免疫性疾病的发生。在肿瘤领域,越来越多的研究发现恶性肿瘤细胞的增殖和侵袭与患者的自身免疫调节功能失衡密切相关。卵巢癌是常见的妇科恶性肿瘤之一,发病率居妇科肿瘤第三位,致死率占妇科恶性肿瘤首位,其发病隐匿,侵袭力强,转移较快,一直以来缺乏强有力的治疗手段。通过对CD4+CD25+Treg的概述以及现有涉及CD4+CD25+Treg与卵巢癌研究进展的综述,寻求在免疫学水平上卵巢癌的早期诊断以及治疗的新方法,从而提高患者的生存率。

Regulatory T cell is a kind of special T cell subpopulation with immunoregulatory function.Among them,CD4+CD25+Treg cell subpopulation is the most widely studied,and its important role is to regulate the immune tolerance function of the body.It can inhibit the activation and proliferation of CD8+and CD4+effector T cells by direct contact,and then prevent the occurrence of autoimmune diseases.In the field of tumor,more and more studies have found that the proliferation of cancer cells is closely related to the invasion and the imbalance of patients′autoimmune regulation.Ovarian cancer is one of the most common gynecological malignancies.With the incidence ranking the third,the death rate of ovarian cancer accounts for the first place in gynecological malignant tumors.It has the characteristics of occult incidence,strong invasion,rapid metastasis,and lack of powerful treatment.The purpose of this article is to seek new methods for the early diagnosis and treatment of ovarian cancer at the immunological level,so as to improve the survival rate of patients through the overview of CD4+CD25+Treg and the review of the current progress of studies on CD4+CD25+Treg and ovarian cancer.