新型冠状病毒肺炎合并心血管基础疾病的临床特点及心肌损伤的病理生理机制

Clinical characteristics of coronavirus disease 2019 combined with cardiovascular diseases and the pathophysiological mechanisms of myocardial injury

新型冠状病毒肺炎(COVID-19)自暴发以来,已造成全球大流行。其心血管损伤的临床表现主要包括心律失常、心原性休克和急性心肌损伤等。而合并心血管基础疾病的COVID-19患者疾病进展更迅速,死亡率更高。本文对细胞因子风暴和血管紧张素转换酶2表达失衡导致心脏损伤进行文献复习,希望对制定临床对策有一定的启示作用。

The new coronavirus pneumonia(coronavirus disease 2019,COVID-19)has caused a global pandemic since the outbreak.The clinical manifestations of cardiovascular injury mainly include arrhythmia,cardiogenic shock and acute myocardial injury.COVID-19 patients with cardiovascular diseases have more rapid progression and higher mortality.This article reviews the literature on cytokine storm and angiotensin converting enzyme 2 expression imbalance leading to cardiac damage,hoping to have some enlightenment for formulating clinical strategies.