儿童革兰阳性球菌感染现状及疾病治疗负担

Gram-positive cocci infection status in children and burden of disease treatment

革兰阳性球菌是造成儿童时期皮肤和皮肤软组织感染、细菌性中耳炎、鼻窦炎、扁桃体咽炎、肺炎、心内膜炎、脓毒症、中枢神经系统感染、骨关节化脓性感染、部分腹腔和泌尿道感染等疾病的重要致病菌之一。革兰阳性球菌感染的患儿数量众多、其对抗菌药物的耐药率在动态增长乃至出现多重耐药,使临床治疗面临挑战。现重点概述革兰阳性球菌感染的现状、耐药性及治疗负担等。

Gram-positive cocci are one of the important pathogens that cause diseases such as skin and skin soft tissue infections,bacterial otitis media,sinusitis,tonsillopharyngitis,pneumonia,endocarditis,sepsis,central nervous system infections,osteoarthritis suppurative infections,partial abdominal cavity and urinary tract infections in children.The clinical treatment of Gram-positive cocci infections is faced with challenges of a large number of infected children,an increasing antimicrobial resistance rate and the appearance of multi-drug resistance.In this article,the current status,drug resistance and treatment burden of Gram-positive cocci infections in children were mainly discussed.