玉屏风辅助治疗小儿哮喘有效性的Meta分析

Meta-analysis of the effectiveness of Yupingfeng in the adjuvant treatment of asthma in children

目的系统评价玉屏风(防风、黄芪、白术)辅助治疗小儿哮喘的有效性及安全性。方法检索中文数据库(中国知网、万方、重庆维普、中国生物医学文献数据库),英文数据库(PubMed、Embase、Elsevier),检索时间为1990年1月—2019年4月。检索关键词为"玉屏风、哮喘、yupingfeng powder、Jade-Screen Powder、asthma"。筛选检索的文章并在RevMan 5.1.5.0软件上进行Meta分析。结果在选择的14篇研究中,共有1 642例患者。Meta分析结果显示:在玉屏风辅助治疗下,小儿哮喘总有效率明显优于常规治疗(P<0.00001);治疗组在PEF改善方面较对照组要明显(P=0.0005);并且治疗组复发率要明显小于对照组(P<0.00001)。结论玉屏风辅助治疗小儿哮喘具备更好的有效性及安全性。

Objective To systematically evaluate the effectiveness and safety of Yupingfeng(Saposhnikovia divaricata,Astragalus membranaceus and bighead atractylodes rhizome)in the adjuvant treatment of asthma in children.Methods Search in the Chinese database(China Knowledge Network,Wanfang,Chongqing Weipu,China Biomedical Literature Database),English database(PubMed,Embase,lsevier),using the key words Yupingfeng,Asthma,Yupingfeng powder,Jade-Screen Powder,and asthma.Retrieval interval from 1990 to April 2019.The retrieved articles were filtered and basic information and related data were extracted,and then meta-analysis was performed on RevMan 5.1.5.0 software.Results Of the 14 studies selected,there were a total of 1642 patients.Meta-analysis results showed that under the adjuvant treatment of Yupingfeng,the total effective rate were better than conventional treatment(P<0.00001).The improvement of PEF in the treatment group was more than that of the control group(P=0.0005).The recurrence rate of the treatment group was lower than that of the control group(P<0.00001).Conclusions Yupingfeng has a better efficacy and safety in the adjuvant treatment of asthma in children.