摘要
高尿酸血症与高血压、糖尿病、冠心病等很多难治愈的疾病呈相关性。高尿酸血症的病因主要是由于人体嘌呤代谢紊乱从而引起人体内尿酸生成过多或排泄失衡。治疗高尿酸血症的方法可以从不同途径对黄嘌呤氧化酶的活性产生抑制作用从而抑制尿酸产生,也可以通过下调负责尿酸重吸收的尿酸转运子肾尿蛋白转运体-1、葡萄糖转运子-9的表达或者上调促进尿酸排泄的转运子如OAT1、OAT3、ABCG2的表达增加尿酸排泄。本文通过查阅文献,对中药单体、复方治疗高尿酸血症的一些实验方法和研究现状做出综述。
Hyperuricemia is associated with hypertension,diabetes,coronary heart disease and many other refractory diseases.The main cause of hyperuricemia is the imbalance of uric acid production or excretion due to the disorder of purine metabolism.The treatment of hyperuricemia can inhibit uric acid production by inhibiting the activity of xanthine oxidase from different pathways,or by downregulating the expression of uric acid transporter renal urine protein transporter-1,glucose transporter-9,which is responsible for uric acid reabsorption,or by upregulating the expression of transporters that promote uric acid excretion such as OAT1,OAT3,ABCG2 to increase uric acid excretion.This paper reviews the experimental methods and research status of Chinese medicine monomer and compound in treating hyperuricemia by consulting literature.
作者
张静文
刘继平
Zhang Jingwen;Liu Jiping(Department of Pharmacology,Shaanxi University of traditional Chinese Medicine,Shanxi Xianyang,712046)
出处
《医学食疗与健康》
2020年第19期221-222,共2页
Medical Diet and Health
基金
陕西省教育厅重点科研计划(15JS022)。
关键词
高尿酸血症
中药
黄嘌呤氧化酶
hyperuricemia
Traditional Chinese Medicine
Xanthine oxidase
