离散偶极近似仿真金属调制稀土荧光及应用研究

Discrete Dipole Approximation Assisted Metal Modulation of Rare Earth Fluorescence and Application

上转换荧光材料由于具有独特的反斯托克斯发射、激发光成像深、自发荧光低、物理化学性质稳定等特点,因此作为影像药剂被广泛研究,在生物医疗领域的应用也得到了不断的发展,但较低的发光效率制约了其发展。金属纳米粒子具有独特的局域表面等离子共振效应,可以有效地增强上转换荧光。本文主要综述离散偶极近似仿真对金属调制荧光的理论指导、实验验证和生物应用。离散偶极近似仿真能够计算纳米粒子电磁特性,可以预测等离子共振峰的位置和强度,从而指导设计金属增强稀土荧光的结构,并对其荧光性能进行测试验证。综述中共涉及了六种不同的稀土-金属复合结构,都获得了金属增强荧光的效果,并实现了其在生物成像和治疗领域的应用。

Up-conversion luminescence material has been widely studied as the imaging agent due to its unique characteristics of anti-Stokes emission,deep excitation light imaging,low background self-fluorescence,and stable physical/chemical property,thus its application has been developed gradually.However,the low efficiency restricts the application in the biomedical field of up-conversion luminescent materials.Metal nanoparticles have unique local surface plasmon resonance and can effectively enhance fluorescence intensity.In this paper,discrete dipole approximation simulation of metal modulation to rare earth from theoretical guidance and experimental verification to biological use were reviewed.The electromagnetic characteristics of the composite can be obtained by the simulation,and plasma resonance peak(position and intensity)can be predicted,in order to guide the design and synthesis with the final luminescence test validation.In this review,six typical different rare earth-metal composites were designed and synthesized with enhanced fluorescence effect,and the application in biological imaging and therapy field was implemented.