Changed serum levels of neurotrophic factors and their correlations with sleep and cognition in patients with chronic insomnia disorder

Objective To explore serum levels of brain-derived neurotrophic factor(BDNF)and glial-derived neurotrophic factor(GDNF),and whether changes of BDNF and GDNF are correlated with sleep quality and cognitive function in patients with chronic insomnia disorder(CID).Methods Fifty-seven CID patients in the Department of Sleep Disorders,Chaohu Hospital of Anhui Medical University and 30 healthy controls were enrolled from May 2017 to July 2018.