新型5-取代苯基的呋喃类化合物的合成

Synthesis of 5-Substituted Phenyl Furan Derivatives

以N,N′-二甲基丙二胺为原料,经Boc保护反应,与5-溴糠醛进行还原胺化反应,最后采用催化剂1,1′-二叔丁基膦基二茂铁二氯化钯与一系列的不同取代的苯硼酸进行Suzuki反应制备得到以呋喃为母核的多取代新型化合物5a^5e,结构经1H NMR和HR-MS(ESI-TOF)表征。

Via BOC protected reaction,the raw material N,N-dimethylpropanediamine reacted with 5-bromofurfural in reductive amination,then the polysubstituted compound 5a^5e with a furan core was prepared by Suzuki reaction of the catalyst 1,1′-di-tert-butylphosphinoferrocene palladium chloride with a series of different substituted phenylboronic acids.The structures were characterized by 1H NMR and HR-MS(ESI-TOF).