β-L-2′-脱氧胞苷的合成

Synthesis ofβ-L-2′-deoxycytidine

β-L-2′-脱氧胞苷为重要的医药中间体。以2′-脱氧-L-核糖和胞嘧啶为起始原料,通过甲苷化、酯化、氯代、水解脱保护基等步骤,以49.7%的收率合成了β-L-2′-脱氧胞苷,HPLC纯度达99.9%。产物结构经1H NMR,13C NMR和MS确证。

β-L-2′-deoxycytidine is an important pharmaceutical intermediate,and its synthesis methods are seldom disclosed at home and abroad.In this paper,taking 2′-deoxyl-ribose and cytosine as starting materials,the yield ofβ-l-2′-deoxycytidine was obtained at 49.7%through the steps of methylization,esterification,chlorination,and off-protecting group,etc.After purification,the purity of HPLC reached 99.9%.The structure of the product was confirmed by 1H NMR,13C NMR and MS.