摘要
近年来围绕注射用丹参多酚酸(SAFI)及其水溶酚酸类成分在卒中后抑郁及卒中后意识障碍中的脑保护作用开展了大量药理作用及药理机制的研究。从抗炎、抗氧化、抗细胞凋亡3个方面,对SAFI及其酚酸类成分(包括丹酚酸B、迷迭香酸、丹酚酸C、丹参素、原儿茶酸)在卒中后抑郁和卒中后意识障碍中的脑保护作用及其机制进行总结,以期为SAFI在临床上优化卒中康复治疗方案提供理论依据。
In recent years,numerous pharmacological and mechanism studies have been conducted on the cerebral protection of Salvianolic Acids for Injection(SAFI)and its aqueous depsides in post-stroke depression(PSD)and post-stroke cognitive impairment(PSCI).This article summarized the cerebral protective mechanisms of SAFI and its aqueous depsides(including salvianolic acid B,rosmarinic acid,salvianolic acid C,danshensu and protocatechuic acid)in PSD and PSCI from the aspects of antiinflammatory,anti-oxidant and anti-apoptosis,to provide theoretical basis for clinical application of SAFI and optimizing rehabilitation programs of stroke.
作者
梁佳威
勾向博
万梅绪
张燕欣
李德坤
汤依群
鞠爱春
LIANG Jiawei;GOU Xiangbo;WAN Meixu;ZHANG Yanxin;LI Dekun;TANG Yiqun;JU Aichun(School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 210009,Jiangsu,China;School of Basic Chemistry and Chemistry Engineering,Tianjin University of Technology,Tianjin 300384,China;Tianjin Tasly Pride Pharmaceutical Co.,Ltd.,Tianjin 300410,China;Tianjin Key Laboratory of Safety Evaluation Enterprise of Traditional Chinese Medicine Injections,Tianjin 300410,China)
出处
《药物评价研究》
CAS
2020年第8期1489-1495,共7页
Drug Evaluation Research
基金
天津市科技重大专项与工程(18ZXXYSY00120)。
关键词
注射用丹参多酚酸
丹酚酸B
迷迭香酸
丹酚酸C
丹参素
脑保护
卒中后抑郁
卒中后意识障碍
Salvianolic Acids for Injection(SAFI)
salvianolic acid B
rosmarinic acid
salvianolic acid C
danshensu
cerebral protection
post-stroke depression
post-stroke cognitive impairment
