注射用丹参多酚酸联合氨氯地平、阿托伐他汀对高血压患者内皮功能的影响

Effect of Salvianolic Acid for Injection combined with amlodipine and atorvastatin on endothelial function in patients with hypertension

目的探讨注射用丹参多酚酸联合氨氯地平、阿托伐他汀对高血压患者内皮功能的影响及安全性。方法选取2018年3月—2019年3月兰考中心医院收治的高血压患者126例,按入院先后顺序分为对照组和观察组(各63例)。对照组在常规治疗的基础上口服氨氯地平5 mg+阿托伐他汀10 mg联合治疗,观察组在对照组治疗的基础上+注射用丹参多酚酸0.13 g静脉滴注,所有患者均治疗14 d。于治疗前后对两组患者的收缩压(SBP)、舒张压(DBP)、C-反应蛋白(CRP)、一氧化氮(NO)、内皮素-1(ET-1)水平和不良反应进行比较。结果治疗后,两组患者SBP、DBP水平均明显下降,与同组治疗前比较差异均有显著性(P<0.05),且观察组SBP下降水平明显优于对照组(P<0.05);两组CRP、ET-1水平均较治疗前明显下降、NO水平明显升高(P<0.05),且观察组优于对照组(P<0.05)。治疗过程中,对照组患者不良反应发生率为14.29%,观察组为12.70%,两组比较无差异。结论对高血压患者在氨氯地平、阿托伐他汀钙片联合治疗的基础上应用注射用丹参多酚酸,可以明显提高治疗效果,改善患者内皮功能,值得进一步临床研究与应用。

Objective To investigate the effect and safety of Salvianolic Acid for Injection combined with amlodipine and atorvastatin on endothelial function in patients with hypertension.Methods A total of 126 patients with hypertension in Lankao Central Hospital from March 2018 to March 2019 were selected,according to the order of admission,they were divided into control group and observation group(63 cases in each group).The control group was given amlodipine 5 mg and atorvastatin 10 mg oral on the conventional treatment,while the observation group was given Salvianolic Acid for Injection of 0.13 g on the basis of control group,all patients were treated for 14 days.Systolic blood pressure(SBP),diastolic blood pressure(DBP),C-reactive protein(CRP),nitric oxide(NO)and endothelin-1(ET-1)and adverse reactions were detected and compared between the two groups before and after treatment.Results After treatment,the levels of SBP and DBP in the observation group were significantly decreased,compared with the same group before treatment,the difference was significant(P<0.05),and DBP level of the observation group was significantly better than that of the control groupt(P<0.05);the levels of CRP and ET-1 in the two groups were significantly decreased,and the level of NO was significantly increased,compared with that before treatment in the same group,the differences were significant(P<0.05),and the difference between two groups was also significant(P<0.05).During the treatment,the incidence of adverse reactions in the control group was 14.29%,and the observation group was 12.70%,there was no significant difference in the incidence of adverse reactions between two groups.Conclusion On the basis of amlodipine and atorvastatin added Salvianolic Acid for Injection,it can significantly improve the treatment effect and improve the endothelial function of patients,which is worthy of further clinical research and application.