从COVID-19免疫相关发病机制探讨免疫抑制剂治疗的应用

Immunosuppressive therapy for the treatment of COVID-19 in terms of immunopathogenesis

2019年12月以来,全球暴发COVID-19大流行,严重威胁人类的生命健康。本文从COVID-19免疫相关发病机制出发,分析病毒感染机体引起的免疫系统变化、淋巴细胞减少及细胞炎症因子风暴等,并对目前免疫抑制剂在COVID-19治疗上使用的现状及优缺点进行综述,探讨有效的免疫抑制剂治疗方法,为临床应用提供参考依据。

Since December 2019,the global outbreak of COVID-19 has posed a serious threat to the lives and health of people in the world.Based on the immunopathogenesis of COVID-19,this article analyzed the changes in the immune system,lymphopenia and cytokine storm caused by 2019-nCoV infection,and summarized the present situation and the advantages and disadvantages of immunosuppressants for the treatment of COVID-19,aiming to explore effective immunosuppressive therapy and provide reference for clinical application.