精神分裂症及其健康同胞额颞环路功能异常的研究

Abnormal Connectivity in the Frontal-temporal Circuit at Rest Are Shared in Schizophrenia and Their Healthy Siblings

目的:研究精神分裂症(schizophrenia patients,SCZ)及其健康同胞(Healthy siblings,SIB)静息态下额颞环路的功能连接异常,为阐明额叶和颞叶在精神分裂症遗传易感性方面的重要作用提供新的证据。方法:研究入组SCZ、SIB,以及健康对照各27例。以既往研究所发现的静息态下SCZ及其SIB均有的局部脑功能活动异常的颞环路上的两个脑区为功能连接分析的感兴趣区,计算并比较各组的感兴趣区与全脑的脑区的功能连接强度的差异。结果:SCZ与其SIB都存在左侧颞中回与对侧额叶亚区(右侧眶额回和右侧额上回)、同侧颞叶其他亚区(左侧颞下回)的功能连接下降;以及左侧眶额回与对侧颞叶亚区(右侧颞中回)的功能连接下降。结论:本研究结果表明精神分裂症的遗传易感性可能不仅与额颞环路上的局部脑区功能活动异常有关,而且还与其对侧额颞通路的脑区间功能整合障碍有关。

Objective:We sought to investigate the functional connectivity alterations in frontal-temporal circuit among schizophrenia patients,healthy siblings and healthy controls.Methods:27 pairs of schizophrenia patients and their healthy siblings,as well as 27 healthy controls,were scanned using gradient-echo echo-planar imaging at rest.By using the abnormal local resting-state activity of frontal and temporal lobe sub-regions found in our previous study as the regions of interest,we investigated the functional connections between the frontal-temporal lobes sub-regions in three groups.Results:We observed that decreased middle temporal gyrus seed-frontal lobe sub-regions connectivity and decreased orbitofrontal gyrus seed-temporal lobe sub-regions connectivity were shared by patients and their healthy siblings.Conclusion:This altered resting-state frontal-temporal circuit shared by schizophrenia patients and their healthy siblings may improve our understanding of neuropathology and genetic predisposition in schizophrenia.