甲状腺抗体阳性与冠状动脉粥样硬化的相关性研究

Correlation study between positive thyroid antibody and coronary arterial atherosclerosis

目的探讨甲状腺抗体阳性与冠状动脉粥样硬化的相关性。方法回顾性分析2019年5月—2020年3月因胸闷或胸痛行冠状动脉造影检查,同时行甲状腺功能及自身抗体滴度测定的100例患者的临床资料,根据甲状腺过氧化物酶抗体(TPO-Ab)滴度不同分为TPO-Ab滴度增高组(n=42)和TPO-Ab滴度正常组(n=58)。比较2组患者冠状动脉粥样硬化发生率、Gensini积分情况及相关性。结果TPO-Ab滴度增高组的冠状动脉粥样硬化发生率、Gensini积分均高于TPO-Ab滴度正常组,差异有统计学意义(P<0.05)。经Spearman相关性分析发现,TPO-Ab滴度增高与Gensini积分呈正相关(P<0.05)。结论甲状腺抗体TPO-Ab阳性与冠状动脉粥样硬化程度呈正相关,冠脉病变越严重,患者的TPO-Ab水平越高,可作为判断冠心病严重程度的重要指标。

Objective To investigate the correlation between positive thyroid antibody and coronary arterial atherosclerosis.Methods The clinical data of 100 patients who underwent coronary angiography for chest distress or chest pain from May 2019 to March 2020,and who also performed thyroid function and autoantibody titer determination were retrospectively analyzed.According to the different thyroid peroxidase antibody(TPO-Ab)titer,the patients were divided into increased TPO-Ab titer group(n=42)and normal TPO-Ab titer group(n=58).The incidence of coronary arterial atherosclerosis in two groups and its relationship with Gensini score were compared and analyzed.Results The incidence of coronary arterial atherosclerosis and Gensini score in increased TPO-Ab titer group were higher than those in normal TPO-Ab titer group(P<0.05).Spearman correlation analysis found that the increase in TPO-Ab titer was positively correlated with Gensini score(r>0,P<0.05).The linear regression equation was obtained by general linear regression test:Y=5.950+3.439X,95%CI:0.140-0.293,t>0,P<0.05.Therefore,the degree of coronary artery disease was closely related to the TPO-Ab titer.Conclusion Positive thyroid antibody TPO-Ab is positively correlated with the degree of coronary arterial atherosclerosis.The more severe the coronary artery disease,the higher the level of TPO-Ab in the patient,which is an important indicator for judging the severity of coronary heart disease.