原发性干燥综合征患者维生素D3的水平与其病情严重程度的关系

Relationship between vitamin D3 levels and severity of primary Sjogren’s syndrome

目的:探讨原发性干燥综合征患者体内维生素D3的水平与其病情严重程度的关系。方法:将2017年1月至2019年9月期间广东省封开县中医院收治的38例原发性干燥综合征患者和同期进行健康体检的38例健康人作为研究对象。将其中19例稳定期原发性干燥综合征患者作为研究A组,将19例活动期原发性干燥综合征患者作为研究B组,将其中38例健康人作为参照组。然后,比较三组研究对象各项检测指标。结果:与参照组体检者相比,研究A组患者和研究B组患者1,25(OH)2D3的水平、CD27浆细胞的占比、记忆性B细胞的占比及IL-10的水平均较低,其TNF-α的水平、IL-6的水平及IL-17的水平均较高,P<0.05。与研究A组患者相比,研究B组患者1,25(OH)2D3的水平、CD27浆细胞的占比、记忆性B细胞的占比及IL-10的水平均较低,其TNF-α的水平、IL-6的水平及IL-17的水平均较高,P<0.05。结论:原发性干燥综合征患者体内维生素D3的水平与其病情的严重程度密切相关。因此,对此病患者进行维生素D3检测有助于判断其病情的严重程度。

Objective:To investigate the relationship between the vitamin D3 level and the severity of primary Sjogren’s syndrome.Methods:38 patients with primary Sjgren’s syndrome admitted to Fengkai County Hospital of Traditional Chinese Medicine in Guangdong province from January 2017 to September 2019 and 38 healthy people who underwent physical examination during the same period were selected as study subjects.Among them,19 patients with stable primary Sjogren’s syndrome were taken as study group A,19 patients with active primary Sjogren’s syndrome were taken as study group B,and 38 healthy patients were taken as reference group.Then,the three groups of subjects were compared for each detection index.Results:compared with those in the reference group,the level of 1,25(OH)2D3,the proportion of CD27 plasma cells,the proportion of memory B cells and the level of il-10 were all lower in study group A and study group B,and the levels of TNF-,il-6 and il-17 were all higher(P<0.05).Compared with study group A,study group B had lower levels of 1,25(OH)2D3,proportion of CD27 plasma cells,proportion of memory B cells and il-10,and higher levels of TNF-,il-6 and il-17(P<0.05).Conclusion:The level of vitamin D3 in patients with primary Sjogren’s syndrome is closely related to the severity of the disease.Therefore,vita min D3 testing is helpful to determine the severity of the dise ase in this patient.