慢性阻塞性肺疾病患者骨骼肌功能和结构的变化及传统功法对其的影响

Changes of skeletal muscle function and structure in patients with chronic obstructive pulmonary disease and effects of traditional Chinese medical exercise intervention

骨骼肌功能障碍是慢性阻塞性肺疾病(简称"慢阻肺")肺外效应的一种突出表现。由于活动水平低、系统性炎症、低血氧等原因,在本病早期就会出现骨骼肌质量减少、横截面积变小,肌纤维总量减少、类型转变,毛细血管分布密度减小,线粒体功能障碍等结构及代谢特征变化,造成患者骨骼肌肌力减弱、耐力降低,影响患者的运动表现,增加其住院率及死亡率,严重影响其生活质量。传统功法作为中国特有的一种运动形式,属于中低强度的有氧运动,可以通过降低慢阻肺患者体内炎症因子水平、改善血氧水平等,有效减缓和改善其骨骼肌结构变化,改善其肌肉力量,增强其肌肉耐力,是一种有效的运动康复手段。

Skeletal muscle dysfunction is a prominent manifestation of extrapulmonary effect of chronic obstructive pulmonary disease(COPD). Due to the low physical activity level, systemic inflammation, hypoxia and other reasons, changes in structural and metabolic characteristics that occur in the early stage of the disease, including skeletal muscle mass reduction, cross-sectional muscle area decrease, reduction of total muscle fiber amount, muscle fiber-type shifting, capillary density decrease, mitochondrial dysfunction, etc., may cause weakening of skeletal muscle strength and endurance of patients, affect their exercise performance, increase hospitalization rate and mortality rate, and seriously affect their quality of life. As a unique form of exercise in China, traditional Chinese medical exercise(Gongfa) belongs to the low and moderate intensity aerobic exercise and is an effective exercise rehabilitation method as it can effectively slow down and improve the structural changes of skeletal muscle, improve its muscle strength and enhance its muscle endurance by reducing the level of inflammatory factors and improving blood oxygen level in COPD patients.