124例萎缩性舌炎相关因素分析

Related factors of atrophic glossitis in 124 consecutive cases

目的:分析萎缩性舌炎(atrophic glossitis,AG)与贫血及相关因子、贫血类型及其他相关因素(口腔念珠菌感染、口干症)的关系。方法:收集124例萎缩性舌炎患者和53例健康对照者,检测2组血红蛋白(Hb)、平均红细胞体积(MCV)、维生素B12、铁蛋白、叶酸含量、是否伴贫血及贫血类型、是否伴口干症及念珠菌感染。采用SPSS 20.0软件包对数据进行统计学分析。结果:124例患者中,伴发贫血占48.39%,伴发口干症占41.94%,伴发念珠菌感染占79.03%。伴维生素B12缺乏占29.03%,伴铁蛋白缺乏占22.58%,伴叶酸缺乏占11.29%。舌炎组血红蛋白、铁蛋白、维生素B12含量显著低于对照组(P<0.05),伴发贫血、口干症和念珠菌感染人数显著高于对照组(P<0.05)。结论:萎缩性舌炎发生与贫血、维生素B12缺乏、铁蛋白缺乏、口干症、口腔念珠菌感染密切相关,与叶酸缺乏不存在相关性。萎缩性舌炎伴发贫血患者中,伴大细胞性贫血情况尤为突出。

PURPOSE:To study the relationship between atrophic glossitis and anemia,anemia types and other related factors(oral candida infection,xerostomia)in 124 consecutive cases.METHODS:One hundred and twenty-four cases with atrophic glossitis and 53 healthy controls were collected from Qingdao local population.The main indexes including general status,oral examination findings,hemoglobin(Hb),mean red blood cell volume(MCV),vitamin B12,ferritin,folic acid,anemia and anemia type,xerostomia and candida infection were statistically analyzed using SPSS 20.0 software package for Student’s t test.RESULTS:Among 124 cases of glossitis group,48.39%were found with anemia,41.94%with xerostomia,79.03%with Candida infection,29.03%with Vitamin B12 deficiency,22.58%with ferritin deficiency,11.29%with folic acid deficiency.The contents of hemoglobin,ferritin and vitamin B12 in glossitis group were significantly lower than those in the control group(P<0.05),and the number of glossitis patients with anemia,xerostomia and candida infection were significantly higher than those in the control group(P<0.05).There was no significant difference in folic acid content between the two groups(P<0.05).CONCLUSIONS:Occurrence of atrophic glossitis is closely related to anemia,vitamin B12 deficiency,ferritin deficiency,xerostomia,oral candida infection.There is no correlation with folic acid deficiency.Patients with atrophic glossitis accompanied by anemia have a higher proportion of macrocytic anemia.