血尿酸、血脂、同型半胱氨酸水平与帕金森患者认知、情绪障碍的相关性研究

The relation between uric acid,serum lipid,homocysteine level and the cognition,emotion impairmentof patients WITH Parkinson’s disease

目的探索尿酸、血脂、同型半胱氨酸水平在帕金森患者中与认知、情绪的相关性。方法回顾性分析2016年1月—2019年9月在本院住院诊断为帕金森病患者65例的临床资料,将患者分为认知正常组、认知障碍组及情绪正常组、情绪障碍组,对血尿酸、血脂、同型半胱氨酸等指标并进行统计分析。结果认知障碍组患者出现高尿酸血症比例低于认知正常组,甘油三酯、同型半胱氨酸升高比例高于认知正常组(P<0.05);情绪障碍组中甘油三酯、同型半胱氨酸升高者比情绪正常组高,差异有统计学意义(P<0.05)。结论尿酸降低、甘油三酯、同型半胱氨酸升高可能与帕金森病患者出现认知、情绪障碍相关。

Objective To explore the relationship between uric acid,serum lipid,homocysteine level and the cognition,emotion impairment of patients with Parkinson’s disease(PD).Methods The clinical date of 65 PD patients those hospitalized and diagnosed in the hospital from January 2016 to September 2019 were retrospectively analyzed.The patients were divided into cognitive normal group,cognitive impairment group,emotional normal group,emotional disorder group.The level of uric acid,serum lipid,homocysteine were compared among the four groups.Results The proportion of hyperuricemia in cognitive impairment group was lower than that in cognitive normal group(P<0.05),and the ratio of increasing triglyceride and homocysteine was higher than that in cognitive normal group(P<0.05).The ratio of increasing triglyceride and homocysteine in emotional disorder group was higher than that in emotional normal group(P<0.05).Conclusions The decrease level of uric acid,increase of triglyceride and homocysteine might correlate with the cognitive and emotional dysfunction in PD patients.